All articles tagged with #multiple sclerosis
Christina Applegate is releasing a memoir, You With the Sad Eyes, about living with multiple sclerosis since her 2021 diagnosis, including earlier battles like breast cancer; she stresses the book is raw and honest rather than inspirational, detailing daily routines and life with her daughter as she considers life beyond on-camera work.
Christina Applegate revealed that her 2021-diagnosed multiple sclerosis has left her largely bedridden with chronic pain, but she cherishes time with her 15-year-old daughter Sadie—especially school drop-offs—and is sharing her journey more openly online. She described how MS has reshaped daily life, noted moments of isolation and limited mobility (including cane use), credited Selma Blair for encouraging testing, and suggested she may not return to acting on screen as she adapts to the condition.
Christina Applegate says she’s bedbound due to multiple sclerosis but still makes time for her 15-year-old daughter Sadie, sharing in a People magazine interview how she tries to take her to school and manages daily life, including a past August hospitalisation for pain as she candidly describes the ongoing battle.
A large-scale study using UK Biobank and All of Us genome data detects EBV reads in a subset of individuals, linking higher EBV load to HIV, immunosuppression, and smoking; GWAS identifies major associations in MHC/HLA and additional loci including ERAP2, with EBV load polygenic burden tied to multiple sclerosis (MHC class I) and rheumatoid arthritis (MHC class II) and overlaps with inflammatory diseases like IBD, hypothyroidism, and type 1 diabetes; proposes host-genome–derived markers of EBV persistence to guide future research and therapy.
A Nature-backed study of biobank DNA data identifies 22 human genes, many in the immune-related HLA region, that correlate with higher EBV DNA levels and chronic disease risk (MS, certain cancers, and related conditions), suggesting genetics may influence why EBV persists and becomes harmful in some people.
A Swedish study analyzed blood from 907 newly diagnosed MS patients and 907 controls, measuring 24 PFAS compounds and seven PCB byproducts. Higher levels of PFAS (notably PFOS) and certain PCB byproducts were linked to roughly double the odds of an MS diagnosis, with the strongest risk when multiple PFAS/byproducts were present, indicating a chemical ‘toxic synergy.’ A gene variant associated with lower MS risk amplified the effect of PFOS exposure, suggesting gene–environment interactions. PFOS and hydroxylated PCBs can cross the blood–brain barrier and may trigger oxidative stress in the brain, potentially contributing to MS symptoms. The study underscores considering chemical mixtures, not single substances, in disease risk; it was published in Environment International.
A HuffPost essay recounts a 13-year medical odyssey in which a woman’s MS symptoms were repeatedly dismissed as non-specific or psychosomatic, with early MRI findings misattributed to migraines and a lumbar puncture only performed years later to confirm MS. Throughout, she faced dismissive, invasive, or patronizing treatment from doctors—especially toward women—and endured a relentless cycle of doubt even after diagnosis. The piece argues this gaslighting reflects broader gender biases in medicine, and it ends with a renewed commitment to advocacy, empathy, and trustworthy care as she continues treatment and healing.
David Faustino says he talks often with Christina Applegate, who lives with multiple sclerosis, as they prepare to reunite with their Married... With Children TV parents Ed O’Neill and Katey Sagal at a charity event in Los Angeles to benefit Race to Erase MS; Faustino praises Applegate’s humor and resilience and notes their longtime friendship.
Indiana quarterback Fernando Mendoza, the Heisman winner, capped a 16-0 season and a national title run by sharing an emotional moment with his wheelchair-bound mother Elsa, who battles multiple sclerosis, and praising her as his inspiration and best friend.
Indiana quarterback Fernando Mendoza, a meteoric rise from a two-star recruit to a top NFL prospect, carries a deeply personal story into the College Football Playoff National Championship: his father consciously stays seated during games to honor Mendoza's mother Elsa, who has had multiple sclerosis for 15 years. The No. 1 seed Hoosiers face the No. 10 seed Miami in the title game at Hard Rock Stadium, as Mendoza pursues Indiana's first national title and cements his historic season.
Jamie-Lynn Sigler revealed she was diagnosed with multiple sclerosis 25 years ago and kept it secret for fear it would end her acting career; she discussed the experience in an ABC interview and later appeared on Grey's Anatomy as a doctor with MS, turning her personal struggle into a storyline that highlights living with the disease.
Scientists at UCL used machine learning to analyze blood tests and brain scans from 634 MS patients, discovering two distinct subtypes of the disease with different progression patterns, which could lead to more personalized treatment approaches.
Scientists have identified two new biological subtypes of multiple sclerosis using AI, blood tests, and MRI scans, which could lead to more personalized and effective treatments for patients by better understanding disease progression and tailoring therapies accordingly.
Research suggests that high levels of the oral bacterium Fusobacterium nucleatum may be linked to increased disability in multiple sclerosis patients, indicating a possible MS-specific oral–brain inflammatory pathway and highlighting the importance of oral health in disease progression.
New research from the University of Basel shows that gut bacteria resembling myelin can trigger or slow multiple sclerosis progression in mice, highlighting both risks and potential for microbiome-based treatments that train the immune system to tolerate myelin.