All articles tagged with #celecoxib
UT Health San Antonio researchers found that low-dose THC combined with the anti-inflammatory celecoxib delayed or reduced Alzheimer’s-like brain changes and improved memory in mice, while THC alone increased inflammatory signals. The study, published in Aging and Disease, suggests this drug combo could move toward clinical trials to slow disease progression, though results in humans remain uncertain.
In two mouse models of Alzheimer's disease, researchers found that very low-dose THC improved memory and reduced brain inflammation, and when combined with celecoxib (a COX-2 inhibitor anti-inflammatory) it led to even stronger benefits, including reduced beta-amyloid plaques and tau tangles and healthier gene activity. THC alone offered limited benefits and increased inflammation; the combo reversed that trend and showed greater cognitive improvement. With both drugs already approved for other uses, the team hopes to move toward human trials to see if the benefits translate to slowing or reversing disease progression.
In mouse models of Alzheimer's, a low-dose THC combined with the anti-inflammatory drug celecoxib improved learning, reduced beta-amyloid and tau pathology, and lowered neuroinflammation, suggesting a feasible path to clinical testing since both drugs are already FDA-approved.