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Mice Study

All articles tagged with #mice study

Mice on Keto Diet Show Hidden Metabolic Trade-Offs
science27 days ago

Mice on Keto Diet Show Hidden Metabolic Trade-Offs

University of Utah researchers fed mice four diets for nine months; those on a keto-style high-fat, low-carb diet gained less weight than a Western high-fat diet but developed fatty liver and impaired liver function in males, with both sexes showing reduced blood glucose and insulin due to impaired pancreatic insulin production. The effects reversed after stopping the diet, but human relevance remains unproven, underscoring potential metabolic trade-offs of ketosis beyond epilepsy uses.

Gaseous Molecule May Shield Brain Against Alzheimer's, Study in Mice Finds
science1 month ago

Gaseous Molecule May Shield Brain Against Alzheimer's, Study in Mice Finds

A Johns Hopkins-led lab study in genetically modified mice showed that slowly releasing hydrogen sulfide (the gas behind fart smells) with NaGYY improved memory and motor function by about 50% after 12 weeks, suggesting hydrogen sulfide signaling might slow neurodegeneration and could inform future Alzheimer’s therapies. Results are preclinical and limited to animal models, though researchers are now exploring the molecular pathways, including interactions with GSK3β, to understand potential human applications.

Psilocybin Shows Promise as a Revolutionary Anti-Aging Treatment
science7 months ago

Psilocybin Shows Promise as a Revolutionary Anti-Aging Treatment

A groundbreaking study found that psilocybin not only extends lifespan in aging mice but also delays cellular aging in human cells, suggesting its potential as a treatment for age-related diseases and healthy aging. The research demonstrated increased survival rates, improved physical health, and cellular markers of reduced aging, though further studies are needed to confirm safety and efficacy in humans.

Reducing Amino Acid Boosts Lifespan in Mice by 33%
science1 year ago

Reducing Amino Acid Boosts Lifespan in Mice by 33%

A study published in Cell Metabolism reveals that reducing the intake of the essential amino acid isoleucine in middle-aged mice can extend their lifespan by up to 33% and improve various health metrics. The research suggests that similar dietary adjustments in humans might offer anti-aging benefits, though translating these findings to human diets is complex. The study highlights the potential of targeting specific amino acids for longevity interventions.

"Reduced Amino Acid Intake Extends Mouse Lifespan by 33%"
health-and-science1 year ago

"Reduced Amino Acid Intake Extends Mouse Lifespan by 33%"

Research in mice suggests that restricting the essential amino acid isoleucine in their diet can increase lifespan and healthspan, reduce frailty, and promote leanness and glycemic control. Male mice experienced a 33% increase in lifespan, while females had a 7% increase. The mice also showed improvements in various health measures. However, applying these findings to humans is complex, as diet is a complex chemical reaction and other dietary components may be involved. The study suggests potential anti-aging effects in humans through isoleucine restriction, but further research and potential interventions, such as an isoleucine-blocking drug, are needed.

"Gut Microbiota's Role in Transmitting Social Anxiety and Stress"
health-and-science2 years ago

"Gut Microbiota's Role in Transmitting Social Anxiety and Stress"

A study in Sweden found that transplanting gut microbiota from individuals with social anxiety disorder into mice made the mice more sensitive to social fear, indicating a potential causal role of gut microbiota in the development of social anxiety disorder. The study revealed differences in gut microbiota composition and biochemical changes in mice that received microbiota from individuals with social anxiety disorder, leading to increased social fear responses. The findings highlight the potential influence of gut microbiota on mental health and suggest the microbiota-gut-brain axis as a target for developing novel therapeutics for social anxiety disorder.