Mice on Keto Diet Show Hidden Metabolic Trade-Offs

University of Utah researchers fed mice four diets for nine months; those on a keto-style high-fat, low-carb diet gained less weight than a Western high-fat diet but developed fatty liver and impaired liver function in males, with both sexes showing reduced blood glucose and insulin due to impaired pancreatic insulin production. The effects reversed after stopping the diet, but human relevance remains unproven, underscoring potential metabolic trade-offs of ketosis beyond epilepsy uses.