All articles tagged with #male contraception
A promising non-hormonal, reversible male contraceptive pill called YCT-529 has shown safety and tolerability in early human trials, blocking sperm production without significant side effects, and could offer an alternative to hormonal options like condoms and vasectomies.
Researchers have reported promising results for Nestron gel, a new male contraceptive that reduces sperm count without side effects. In a trial involving 222 men, 86% experienced a significant decrease in sperm count after 12 weeks of daily application. The study aims to provide a viable birth control option for men, though further research is needed to confirm its safety and effectiveness.
Researchers have developed a daily contraceptive gel for men that is applied to the shoulders and has shown promise in early trials by lowering sperm counts in around eight weeks. The gel contains Nestorone and testosterone and is being tested on over 200 men in the US, with 80% of participants reaching low sperm levels within 12 weeks. This method is quicker than other male hormonal contraceptives and aims to share the responsibility of contraception between men and women.
A new non-hormonal male contraceptive, CDD-2807, has shown promising results in mice, effectively reducing sperm activity and being reversible without significant side effects. Researchers at Baylor College of Medicine are optimistic about its potential and plan to test it in non-human primates.
Scientists at the Salk Institute have developed a non-hormonal and reversible male contraceptive pill that targets a specific protein complex involved in sperm production, showing promising results in male mice without apparent side-effects. The method disrupts the genetic program responsible for sperm production using existing drugs called HDAC inhibitors, and once the treatment is stopped, fertility returns to normal. Further research and clinical trials are needed, but this breakthrough offers a potential new option for male birth control with minimal systemic side-effects.
Scientists at Washington State University have identified a gene that, when removed, temporarily renders sperm infertile, paving the way for a potential male contraceptive pill. The protein encoded by this gene is found solely in the testicular tissue of most mammals and reduces sperm counts and deforms remaining sperm to make them incapable of fertilizing an egg when altered. The destabilization of the infertility protein is not permanent, meaning sperm will recover once the person or animal stops taking the pills. The researchers have filed a provisional patent for the development of a male contraceptive based on this gene and the protein it encodes.
Researchers at Washington State University have identified a gene, Arrdc5, that is expressed only in testicular tissue and is found in multiple mammalian species, including humans. Knocking out the gene in male mice created infertility by impacting their sperm count, movement, and shape. The protein encoded by this gene is required for normal sperm production, and the team will work on designing a drug that would inhibit its production or function, making it easily reversible as a contraceptive. The discovery could pave the way for a highly effective, reversible, and non-hormonal male contraceptive for humans and animals.
Researchers from Washington State University have identified a gene called Arrdc5, which could be a potent target in the development of new birth control drugs for men. The gene is only expressed in the testicles of various mammals, including humans. Manipulating the Arrdc5 gene in mice led to infertility in males, and scientists say that a drug targeting this gene could be a sorely needed solution to the massive disparity between male and female contraceptive options. The lack of hormonal involvement in the drug would be ideal, and it should be easy to engineer any such new drug to be reversible.