Tag

Immune Evasion

All articles tagged with #immune evasion

science4 days ago•9 min saved

HIV reservoir clones reveal CTL-driven erosion and intrinsic resistance under immune pressure

Researchers isolated authentic reservoir clones that proliferate and produce infectious HIV under ART, with only small fractions expressing viral proteins at any moment. Prolonged exposure to a CD8+ cytotoxic T-lymphocyte (CTL) clone substantially reduces these clones, showing time-integrated vulnerability to immune pressure, though some ARC exhibit cell-intrinsic resistance linked to low oxidative stress, which can be reversed with deferoxamine. The findings highlight specific immune-escape pathways as targets to enhance HIV cure strategies.

via Nature|

#antigen-expression #cytotoxic-t-cells #hiv

cancer-research3 months ago•31 min saved

Unraveling the Immune Evasion and Genetic Drivers in Colorectal Cancer Progression

The study reveals that TGF-β creates a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages, contributing to immune evasion and tumor progression.

via Nature|

#cancer-research #colorectal-cancer #immune-evasion

cancer-research3 months ago•59 min saved

Key Genetic and Epigenetic Factors Drive Early Bowel Cancer Development

This study explores how epigenetic changes and immune microenvironment interactions drive early immune evasion in colorectal cancer, highlighting chromatin architecture's role in suppressing neoantigen expression and the importance of early immune escape mechanisms in tumor evolution.

via Nature|

#cancer-research #colorectal-cancer #epigenetics

biology5 months ago•89 min saved

Panoptes System Uses Decoy Nucleotides to Combat Phages

The Panoptes system in bacteria uses decoy cyclic nucleotides to defend against phages by detecting phage anti-defense proteins like Acb2 that sequester these signaling molecules, thereby activating membrane-disrupting effectors to prevent phage replication.

via Nature|

#antiphage-systems #bacteria #biology

health5 months ago•3 min saved

Breakthrough in Diabetes Treatment: CRISPR and Bioengineering Enable Immune-Evasive Insulin-Producing Cells

Researchers have successfully implanted CRISPR-edited pancreatic cells into a person with type 1 diabetes, enabling the cells to produce insulin and evade immune detection without immunosuppressive drugs, marking a significant step toward a potential cure for the disease. However, the study involved only one patient and more research is needed to confirm efficacy.

via Nature|

#cell-therapy #crispr #diabetes

science6 months ago•17 min saved

RNA N-glycosylation Facilitates Immune Evasion and Cell Clearance

The study reveals that RNA N-glycosylation plays a crucial role in enabling immune evasion and facilitating homeostatic efferocytosis, highlighting a novel mechanism by which glycoRNAs modulate immune responses and maintain cellular homeostasis.

via Nature|

#efferocytosis #glycorna #immune-evasion

medical-research2 years ago•26 min saved

"SOX17's Role in Immune Evasion of Colorectal Adenomas and Cancers"

A study has found that SOX17 enables immune evasion in early colorectal adenomas and cancers. The research, which utilized RNA-seq data, ATAC-seq data, and single-cell RNA-seq data, sheds light on the role of SOX17 in immune evasion and its potential implications for colorectal cancer treatment. The findings provide valuable insights into the mechanisms underlying immune evasion in colorectal cancer and may contribute to the development of targeted therapies.

via Nature.com|

#colorectal-cancer #immune-evasion #medical-research

health2 years ago•1 min saved

Cancer Cells Hijack Immune Cells' Energy Source

Some cancer cells have been found to extend nanotube projections into T cells, siphoning off mitochondria from the immune cells and rendering them inactive, while energizing the cancer cells. This discovery sheds light on a new mechanism of immune evasion employed by cancer cells, which could explain their resistance to certain immunotherapies.

via STAT|

#cancer-cells #health #immune-evasion

medical-research2 years ago•28 min saved

Enzyme PI3Kβ Promotes Immune Evasion in PTEN-Deficient Breast Tumors.

Researchers have discovered that PI3Kβ plays a crucial role in immune evasion in PTEN-deficient breast tumors. The study found that inhibiting PI3Kβ led to increased immune cell infiltration and improved response to immunotherapy in mouse models. The findings suggest that targeting PI3Kβ could be a potential strategy for enhancing the effectiveness of immunotherapy in breast cancer patients with PTEN-deficient tumors.

via Nature.com|

#breast-cancer #immune-evasion #medical-research

medical-science-news2 years ago•4 min saved

New discoveries in SARS-CoV-2 research and prevention.

A recent study has explored the virological characteristics of the SARS-CoV-2 Omicron XBB subvariant, XBB.1.16, which has two S substitutions, including E180V and T478R in the N-terminal domain (NTD) and receptor-binding domain (RBD), respectively. The study found that XBB.1.16 has immense potential to disseminate and infect people worldwide to a greater extent than XBB.1 and XBB.1.5 subvariants. Furthermore, XBB.1.16 exhibits a higher immune-evasion potential that is similar to that of XBB.1 and XBB.1.5.

via News-Medical.Net|

#immune-evasion #medical-science-news #mutations