All articles tagged with #immune evasion
The study reveals that TGF-β creates a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages, contributing to immune evasion and tumor progression.
This study explores how epigenetic changes and immune microenvironment interactions drive early immune evasion in colorectal cancer, highlighting chromatin architecture's role in suppressing neoantigen expression and the importance of early immune escape mechanisms in tumor evolution.
The Panoptes system in bacteria uses decoy cyclic nucleotides to defend against phages by detecting phage anti-defense proteins like Acb2 that sequester these signaling molecules, thereby activating membrane-disrupting effectors to prevent phage replication.
Researchers have successfully implanted CRISPR-edited pancreatic cells into a person with type 1 diabetes, enabling the cells to produce insulin and evade immune detection without immunosuppressive drugs, marking a significant step toward a potential cure for the disease. However, the study involved only one patient and more research is needed to confirm efficacy.
The study reveals that RNA N-glycosylation plays a crucial role in enabling immune evasion and facilitating homeostatic efferocytosis, highlighting a novel mechanism by which glycoRNAs modulate immune responses and maintain cellular homeostasis.
A study has found that SOX17 enables immune evasion in early colorectal adenomas and cancers. The research, which utilized RNA-seq data, ATAC-seq data, and single-cell RNA-seq data, sheds light on the role of SOX17 in immune evasion and its potential implications for colorectal cancer treatment. The findings provide valuable insights into the mechanisms underlying immune evasion in colorectal cancer and may contribute to the development of targeted therapies.
Some cancer cells have been found to extend nanotube projections into T cells, siphoning off mitochondria from the immune cells and rendering them inactive, while energizing the cancer cells. This discovery sheds light on a new mechanism of immune evasion employed by cancer cells, which could explain their resistance to certain immunotherapies.
Researchers have discovered that PI3Kβ plays a crucial role in immune evasion in PTEN-deficient breast tumors. The study found that inhibiting PI3Kβ led to increased immune cell infiltration and improved response to immunotherapy in mouse models. The findings suggest that targeting PI3Kβ could be a potential strategy for enhancing the effectiveness of immunotherapy in breast cancer patients with PTEN-deficient tumors.
A recent study has explored the virological characteristics of the SARS-CoV-2 Omicron XBB subvariant, XBB.1.16, which has two S substitutions, including E180V and T478R in the N-terminal domain (NTD) and receptor-binding domain (RBD), respectively. The study found that XBB.1.16 has immense potential to disseminate and infect people worldwide to a greater extent than XBB.1 and XBB.1.5 subvariants. Furthermore, XBB.1.16 exhibits a higher immune-evasion potential that is similar to that of XBB.1 and XBB.1.5.