Enzyme PI3Kβ Promotes Immune Evasion in PTEN-Deficient Breast Tumors.

Researchers have discovered that PI3Kβ plays a crucial role in immune evasion in PTEN-deficient breast tumors. The study found that inhibiting PI3Kβ led to increased immune cell infiltration and improved response to immunotherapy in mouse models. The findings suggest that targeting PI3Kβ could be a potential strategy for enhancing the effectiveness of immunotherapy in breast cancer patients with PTEN-deficient tumors.