All articles tagged with #genetic mutations
Scientists discovered that the protein MRAP2 supports the appetite-regulating receptor MC3R, and mutations in MRAP2 can impair this support, potentially leading to obesity. This insight could pave the way for new obesity treatments targeting MRAP2 to improve appetite regulation.
A study reveals that polar bears in southern Greenland are using 'jumping genes' to rapidly modify their DNA as a survival response to melting sea ice caused by climate change, though the threat to their survival remains significant.
Researchers have discovered that activating transposable elements in certain blood cancers with specific mutations creates a vulnerability that can be exploited using PARP inhibitors, leading to cancer cell death without harming healthy cells, offering a new potential treatment for drug-resistant blood cancers.
Scientists from UW-Madison discovered that the protein RPA is crucial for maintaining chromosome stability by stimulating telomerase, providing new insights into the causes of unexplained, deadly diseases related to short telomeres, and offering potential for improved diagnosis and treatment.
A study shows that sperm from older men carry more genetic mutations, including potentially harmful ones, which increases the risk of genetic diseases in offspring. The research highlights that mutations accumulate with age and are subject to positive selection, raising concerns about reproductive planning and genetic counseling for older fathers.
A Phase III trial found that adding niraparib, a PARP inhibitor, to standard treatment significantly delays progression of advanced prostate cancer in men with specific DNA repair gene mutations, suggesting a promising personalized therapy approach, despite some increased side effects.
Research shows that as men age, harmful genetic mutations in sperm become more common due to natural selection favoring certain DNA changes, increasing the risk of passing on genetic disorders to offspring, with implications for reproductive health and genetic inheritance.
Research shows that as men age, harmful mutations in sperm increase and are favored during sperm production, raising the risk of passing on genetic disorders like neurodevelopmental issues and cancer to offspring, due to a process called 'selfish selection.'
In 2023, a 19-year-old in China was diagnosed with Alzheimer's disease, making him the youngest known case. Despite extensive genetic testing, no typical mutations were found, highlighting the complexity and mystery of early-onset Alzheimer's, which may not always be linked to inherited genes. This case challenges existing understanding and underscores the need for further research into the disease's diverse pathways.
A low dose of aspirin daily may significantly reduce the risk of colorectal cancer returning in patients with specific genetic mutations, according to a new clinical trial, offering a cheap and accessible potential treatment option.
A study shows that a low daily dose of aspirin can significantly reduce the risk of colorectal cancer returning after surgery, especially in patients with specific genetic mutations, highlighting the potential for genetic testing to guide preventive treatment.
The article discusses the rising incidence of lung cancer among young, fit, non-smoking women, highlighting cases like Becca Smith's, and explores potential causes such as air pollution, genetic mutations, and hormonal factors, emphasizing the need for more research and awareness.
Scientists observed rapid evolution in fungi on cheese rinds, where a mutation disrupting the alb1 gene led to a color change from green to white, demonstrating how environmental changes can drive genetic adaptation and offering insights for food security and medical research.
A study finds that human egg cells are protected from age-related mitochondrial DNA mutations, unlike blood and saliva cells, suggesting an evolved mechanism that preserves genetic integrity in eggs as women age, which could impact reproductive counseling.
The UK has successfully used mitochondrial donation technology to prevent mitochondrial diseases in eight babies, sparking both hope and controversy due to ethical concerns and potential genetic mutations, with cautious scientific progress deemed essential.