Older Fathers' Sperm Show Increased Harmful Mutations and Positive Selection
TL;DR Summary
Research shows that as men age, harmful mutations in sperm increase and are favored during sperm production, raising the risk of passing on genetic disorders like neurodevelopmental issues and cancer to offspring, due to a process called 'selfish selection.'
- Why Older Fathers Pass on More Harmful Mutations to Their Kids Neuroscience News
- Sperm sequencing reveals extensive positive selection in the male germline Nature
- Selfish sperm see older fathers pass on more disease-causing mutations New Scientist
- Hotspots of human mutation point to clonal expansions in spermatogonia Nature
- Study Finds Positive Selection Shapes Genetic Mutations in Male Germline Through Sperm Analysis geneonline.com
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