Blocking an Aging Enzyme Sparks Cartilage Regrowth Without Stem Cells
TL;DR Summary
Scientists inhibited the aging-associated enzyme 15-PGDH in aged mice with cartilage damage, triggering regeneration of hyaline cartilage without stem cells and showing early repair signals in human cartilage samples; if these findings translate to humans, treatments for osteoarthritis could shift toward direct cartilage restoration rather than surgery, though safety and clinical trials are still needed.
Topics:health#15-pgdh-enzyme#cartilage-regeneration#hyaline-cartilage#osteoarthritis#regenerative-medicine#science
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