Blocking an Aging Enzyme Sparks Cartilage Regrowth Without Stem Cells
Scientists inhibited the aging-associated enzyme 15-PGDH in aged mice with cartilage damage, triggering regeneration of hyaline cartilage without stem cells and showing early repair signals in human cartilage samples; if these findings translate to humans, treatments for osteoarthritis could shift toward direct cartilage restoration rather than surgery, though safety and clinical trials are still needed.