
CKM syndrome: a hidden tri-system link threatens most adults
AHA researchers say cardiovascular–kidney–metabolic (CKM) syndrome links heart, kidney and metabolic problems into one high‑risk cycle, affecting about 90% of U.S. adults with risk factors such as high blood pressure, abnormal cholesterol, high blood sugar, obesity and reduced kidney function. When these issues cluster, the risk of heart attack, stroke and heart failure rises far more than for any single condition. Public awareness is low, but many want to learn about diagnosis and treatment. The AHA is releasing CKM health resources and plans to publish first clinical CKM guidelines in 2026 to promote coordinated care and early action through lifestyle changes and medical management.












