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Blood Stem Cells

All articles tagged with #blood stem cells

science2 months ago•1 min saved

Lab-Grown Embryo Models Pave the Way for Blood Cell Production and Donation Solutions

Researchers at the University of Cambridge have developed embryo-like structures called hematoids from donated human stem cells that can produce red and white blood cells in the lab, potentially supplementing blood donations and advancing treatments for blood disorders. These structures mimic early human blood development and are more self-sustaining than previous methods, marking a significant step toward regenerative therapies.

via ScienceAlert|

#blood-disorders #blood-stem-cells #hematoids

science7 months ago•4 min saved

Innovative Gene Therapies Target Blood Cells for Treating Diseases in Newborns

Researchers have discovered a critical early postnatal period when circulating blood stem cells can be effectively targeted with gene therapy directly in the body, opening new possibilities for treating genetic blood disorders without stem cell transplantation or chemotherapy, with promising results in mouse models and potential applicability to humans.

via SciTechDaily|

#blood-stem-cells #gene-therapy #genetic-disorders

science7 months ago•3 min saved

CRISPR in blood stem cells may cause premature aging, study suggests solutions

A study by the San Raffaele Telethon Institute found that CRISPR-Cas9 gene editing in blood stem cells can induce inflammatory and senescence-like responses, leading to premature aging and reduced regenerative capacity. Researchers propose strategies like transient p53 inhibition and anti-inflammatory treatment with Anakinra to mitigate these effects, potentially improving the safety and efficacy of gene therapies for blood disorders.

via Medical Xpress|

#blood-stem-cells #crispr #gene-editing

health7 months ago•5 min saved

Advances in In Vivo Gene Therapy for Early-Life and Hematopoietic Stem Cells

A new gene therapy approach using a single injection directly into the bloodstream has shown promise in treating inherited blood diseases in mice, especially effective in newborns due to the abundance of circulating blood stem cells, potentially simplifying and expanding access to treatment for conditions like sickle cell disease and Fanconi anemia.

via SingularityHub|

#blood-diseases #blood-stem-cells #gene-therapy

medical-research2 years ago•3 min saved

Unlocking the Potential of Blood Stem Cells from Your Own Blood

A new study has found that a protein receptor called Nod1, known for its role in recognizing bacterial infections, also plays a crucial role in the development of blood stem cells in embryos. This discovery could lead to the ability to produce blood stem cells from a person's own blood, potentially eliminating the need for bone marrow transplants and improving treatment for leukemia, lymphoma, and anemia patients. The research offers hope for regenerative medicine and could pave the way for creating therapeutic-grade blood stem cells to cure blood disorders.

via ScienceAlert|

#blood-stem-cells #embryonic-development #genetic-research

health2 years ago•2 min saved

Unlocking the Fountain of Youth: Decoding the Key to Eternal Youth

Scientists have identified high levels of formaldehyde, a toxic chemical naturally produced by cells, as a potential cause of ageing. Researchers from Cornell, Oxford, Cambridge, and Cancer Research UK are investigating the mechanisms behind formaldehyde production and exploring the development of drugs to lower its levels. A recent study found that formaldehyde damages DNA, leading to accelerated ageing in blood stem cells. The team is also examining if other chemicals contribute to ageing and how to prevent their accumulation. While formaldehyde alone may not be the sole cause of ageing, this research highlights the body's production of measurable chemicals that can lead to significant health problems.

via The Telegraph|

#ageing #blood-stem-cells #dna-damage