Tag

Mrna Therapy

All articles tagged with #mrna therapy

science13 hours ago•23 min saved

Capsule-Filtration-Enabled LNPs Target Pancreas for Precision mRNA Therapies

A Nature study introduces AH-LNP, a pancreatic-targeted lipid nanoparticle whose protein adsorption enlarges it to enable capsule-filtration–driven pancreas accumulation and receptor-mediated uptake, allowing efficient delivery of Cas9 mRNA and sgRNA for genome editing as well as mRNA encoding therapeutic cytokines. The approach yields precise pancreatic gene editing, enhances antitumor responses when combined with vaccines or CAR-T therapy across multiple pancreatic cancer models, and shows safety in several animal models including non-human primates, highlighting a promising platform for precision treatments of pancreatic diseases.

via Nature|

#ah-lnp #crispr-cas9 #lipid-nanoparticles

health1 month ago•3 min saved

Liver signals rekindle aging immune response in mice

Broad Institute researchers show in old mice that injecting mRNA into the liver triggers thymic signals (DLL1, FLT3-L, IL-7), reviving T-cell production. Over four weeks, older mice had more diverse T cells, stronger vaccine responses, and better anti-cancer activity, though the boost was temporary and human trials are needed, with the findings published in Nature.

via ScienceAlert|

#aging #health #immunology

health2 months ago•2 min saved

mRNA and Liver Reprogramming Revitalize Aging Immune Systems

A study demonstrates that a twice-weekly cocktail of three messenger RNAs can rejuvenate aged immune cells in mice, particularly T cells, enhancing their response to vaccines and cancer therapies, by targeting T cells through the liver to counteract age-related decline and thymus degradation.

via Nature|

#aging #cancer-treatment #health

health-and-medicine2 months ago•86 min saved

mRNA Therapy Revitalizes Aging Immune System and Enhances Disease Response

The study presents a novel approach to counteract immune decline in aging by using mRNA delivered to the liver to produce key immune factors (DLL1, FLT3-L, IL-7), which rejuvenates T cell production, enhances vaccine responses, and improves tumor immunotherapy efficacy in aged mice, without adverse effects or autoimmunity.

via Nature|

#health-and-medicine #immune-aging #immunotherapy

science2 months ago•5 min saved

Innovative Approaches to Rejuvenate the Aging Immune System

Researchers at MIT and the Broad Institute have developed a method using mRNA to temporarily program liver cells, creating a 'factory' that produces T-cell survival factors, which rejuvenates the immune system in aged mice and enhances their response to vaccines and cancer treatments. This approach could potentially help maintain immune health in humans as they age.

via MIT News|

#aging #immune-system #mit

science6 months ago•2 min saved

Scientists Develop Broad-Spectrum Antiviral Strategies Using Genetic Insights

Researchers have replicated a rare genetic mutation that grants near-universal virus immunity in lab animals using mRNA technology, offering a potential short-term protective therapy against various viruses, including COVID-19, though challenges remain in delivery and societal acceptance.

via ScienceAlert|

#genetic-mutation #isg15 #mrna-therapy

health6 months ago•4 min saved

mRNA Therapy Shows Promise for Universal Antiviral Treatment

Researchers have developed an experimental mRNA-based therapy that mimics the antiviral powers of a rare immune condition, potentially providing broad protection against viruses like influenza and COVID-19, and serving as a universal antiviral in future pandemics.

via Medical Xpress|

#antiviral #broad-spectrum #health

health1 year ago•4 min saved

"mRNA Therapy Trial Shows Promise in Treating Rare Inherited Disease"

A new mRNA therapy, mRNA-3927, shows promise in treating propionic acidemia, an ultrarare inherited metabolic disorder that affects around 1 in 100,000 people in the U.S. The therapy aims to replenish stocks of working enzymes in the body by using messenger RNA to produce fully functioning enzymes that are otherwise defective in patients with the disease. Initial findings from a pioneering clinical trial suggest a 70% drop in the rate of metabolic decompensation events in patients with propionic acidemia, although the trial has several limitations and is ongoing.

via Livescience.com|

#clinical-trial #enzyme-deficiency #health

healthcare2 years ago•2 min saved

"UK Patients First to Receive Experimental mRNA Cancer Therapy"

Patients in the UK have received an experimental mRNA therapy for melanoma, lung cancer, and other solid tumors at Hammersmith hospital in London. The therapy aims to present tumor markers to the immune system, helping it recognize and fight cancer cells. The trial, known as Mobilize, will assess the therapy's safety and effectiveness, administered alone or in combination with pembrolizumab. Researchers hope this approach may lead to a new treatment option for difficult-to-treat cancers, addressing the need for less toxic and more precise anti-cancer therapies.

via The Guardian|

#cancer-research #cancer-treatment #clinical-trial

health2 years ago•2 min saved

Researchers Discover Groundbreaking Method to Trigger Cancer Cell Suicide

Researchers at Tel Aviv University have successfully induced cancer cell suicide in animals with melanoma by delivering mRNA molecules encoding a bacterial toxin directly to the tumor bed. The nanoparticles carrying the mRNA were injected into the tumors, causing the cancer cells to produce the toxic protein that eventually killed them. This groundbreaking study achieved a success rate of 44% to 60% in eliminating cancer cells without harming healthy cells. The researchers believe this method could be applied to various types of cancer using different natural toxins, offering a promising alternative to chemotherapy.

via The Jerusalem Post|

#bacterial-toxin #cancer-research #health