All articles tagged with #brain cells
A team used a new machine-learning tool called SIGNET to build a cell-type-specific map of gene regulation in brains from 272 Alzheimer's patients, identifying hub genes and thousands of causal interactions—especially in excitatory neurons—offering potential drug targets while noting that causality isn’t proven and comparisons with non-AD tissue are planned.
Researchers discovered that two types of brain immune cells, microglia, act as internal 'accelerators' and 'brakes' to regulate anxiety levels in mice, suggesting new avenues for understanding and treating anxiety disorders in humans.
Researchers have uncovered how a rare genetic mutation in the GPX4 gene causes neurodegeneration through ferroptosis, a form of cell death linked to oxidative damage, providing new insights into diseases like Alzheimer's and childhood dementia.
Recent research reveals that astrocytes, once considered support cells, play crucial roles in shaping behavior, memory, and health by regulating the environment around neurons, influencing brain functions such as circadian rhythms and memory encoding, and potentially contributing to neurological diseases.
A study in mice shows that increasing the protein Sox9 reactivates brain cells' cleanup functions, reducing Alzheimer's-like plaques and improving memory, suggesting a potential new treatment approach targeting brain maintenance cells called astrocytes.
A study in mice shows that increasing the protein Sox9 reactivates brain cells' cleaning functions, reducing Alzheimer's-like plaques and improving memory, suggesting a potential new treatment approach targeting brain maintenance cells called astrocytes.
A study reveals that Alzheimer's disease may hijack the body's cellular clocks, with circadian rhythms controlling many genes linked to the disease, suggesting potential new treatment strategies by manipulating these biological clocks to prevent or slow disease progression.
A study found that individuals with schizophrenia have smaller and differently shaped neurons in the brain's anterior cingulate cortex, with neuron size correlating to hallucination severity, suggesting potential biological markers and targets for future treatments.
Scientists have identified a unique group of microglia with lower PU.1 levels and higher CD28 expression that can protect the brain by reducing inflammation and slowing Alzheimer's pathology, opening new avenues for immunotherapy.
Researchers at the University of Copenhagen identified a rare brain cell type whose overactivity may contribute to schizophrenia symptoms. Reducing the activity of these cells in mice normalized sleep and behavior, suggesting a potential early intervention target before symptoms fully develop. This discovery offers hope for developing precise treatments to prevent cognitive deficits associated with schizophrenia.
A recent study reveals that astrocytes, a type of brain cell previously thought to support neurons, actively stabilize long-term emotional memories, suggesting new targets for treating memory-related conditions like PTSD and Alzheimer's disease.
Michael J. Fox, diagnosed with early-onset Parkinson's at 29, reflects on his 34-year battle with the disease, expressing a wish to not wake up one day due to the progressive decline in motor skills and the impact on his life, including injuries and giving up activities like guitar playing.
Scientists at McGill University have identified two specific types of brain cells—excitatory neurons and microglia—that show changes in individuals with depression, providing new insights into the biological basis of the condition and potential targets for treatment.
Jo Kavaliauskas experiences vivid hallucinations due to schizoaffective disorder, revealing insights into how specialized brain cells may be involved in the origins of hallucinations, and highlighting their desire for a life free from these symptoms.
A study suggests that the high prevalence of autism in humans may be an evolutionary trade-off linked to genetic changes in brain cells that enhanced cognition but increased vulnerability to neurodevelopmental disorders, highlighting natural selection's role in shaping human brain traits and susceptibility.