Alzheimer's Gene Network Map Reveals Hidden Brain Drivers
TL;DR Summary
A team used a new machine-learning tool called SIGNET to build a cell-type-specific map of gene regulation in brains from 272 Alzheimer's patients, identifying hub genes and thousands of causal interactions—especially in excitatory neurons—offering potential drug targets while noting that causality isn’t proven and comparisons with non-AD tissue are planned.
- First-of-Its-Kind Map of Alzheimer's Reveals Hidden Gene Activity ScienceAlert
- Connecting the dots between cause-effect events in Alzheimer's disease Medical Xpress
- Systems genetic dissection of brain gene expression reveals excitotoxic mechanisms of Alzheimer’s disease Nature
- AI uncovers the hidden genetic control centers driving Alzheimer’s ScienceDaily
- Causal gene mapping identifies key drivers of Alzheimer's disease progression News-Medical
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