tldrdaily.news logo
Tag

Antibiotic Resistance

All articles tagged with #antibiotic resistance

Typhoid’s Drug-Resistant Wake-Up Call Goes Global
health20 hours ago

Typhoid’s Drug-Resistant Wake-Up Call Goes Global

The typhoid fever bacterium is rapidly gaining extensive drug resistance and spreading internationally, threatening all oral antibiotics as resistance reaches both frontline drugs and newer treatments like azithromycin. A 2014–2019 genome study of 3,489 S. Typhi samples from South Asia and beyond shows accelerating spread of extensively drug-resistant Typhi, prompting calls for expanded vaccination and new antibiotic research to avert a global typhoid crisis.

via ScienceAlert|
#antibiotic-resistance#azithromycin#health
Ancient ice-borne bacteria resist modern antibiotics
science4 days ago

Ancient ice-borne bacteria resist modern antibiotics

Researchers thawed a 5,000-year-old bacterium from Romania’s Scarisoara cave and found it resistant to 10 of 28 antibiotics, showing that antibiotic resistance evolved naturally in the environment long before humans. The microbe also carries genes that may help kill other microbes, offering potential avenues for new drugs, though warming glaciers could release unknown ancient microbes.

via CNN|
#ancient-bacteria#antibiotic-resistance#ice-cave
Microgravity uncovers space phages that could curb antibiotic resistance
science7 days ago

Microgravity uncovers space phages that could curb antibiotic resistance

A study comparing phage-bacteria dynamics on the ISS and on Earth shows that the T7 phage infecting E. coli slows in microgravity but can still replicate after a long interval. Space conditions drive distinct mutation patterns in both phage and host, and researchers used microgravity-informed mutations to engineer phage variants that outperform Earth-informed ones against drug-resistant uropathogenic E. coli. The findings suggest extreme environments can reveal new design principles for phage therapy to combat antibiotic resistance and are reported in PLOS Biology.

via Earth.com|
#antibiotic-resistance#bacteriophages#evolution
science8 days ago

Ancient Romanian Ice Cave Bacterium Carries 100+ Resistance Genes, Defies 10 Antibiotics

A Frontiers in Microbiology study details Psychrobacter SC65A.3 isolated from a 5,000-year-old ice core in Romania’s Scărișoara Ice Cave. Genomic analysis reveals over 100 antibiotic-resistance genes (and ~600 genes of unknown function) and resistance to ten modern antibiotics, including ciprofloxacin. While thawing ice due to climate change could release resistance genes into contemporary bacteria, the enzymes and compounds from this ancient microbe also offer potential biotechnological applications; the finding underscores the need for monitoring ancient genomes as glaciers and caves thaw and consider implications for antimicrobial resistance.

via Ground News|
#ancient-bacteria#antibiotic-resistance#biotech-potential
Ancient Romanian Ice Bacteria Could Help Fight Superbugs—With Caution
science9 days ago

Ancient Romanian Ice Bacteria Could Help Fight Superbugs—With Caution

Researchers studying a 5,000-year-old Psychrobacter strain from Romania’s Scărișoara Ice Cave found it resistant to multiple modern antibiotics yet capable of inhibiting several antibiotic‑resistant pathogens, suggesting ancient microbes could inspire new antibiotics but also carry a risk of spreading resistance genes if melted; calls for more research into cold-environment microbes and their biotechnological potential.

via ScienceAlert|
#ancient-bacteria#antibiotic-resistance#biotechnology
Spaceflight Drives Bacteria-Phage Evolution, Boosting Attack on Drug-Resistant Infections
science1 month ago

Spaceflight Drives Bacteria-Phage Evolution, Boosting Attack on Drug-Resistant Infections

ISS experiments with Escherichia coli and T7 phage (plus Earth controls) over ~25 days show spaceflight–driven mutations in bacterial stress responses and surface proteins, prompting phage adaptations that continue to kill bacteria. Some space-specific phage mutations were especially effective against antibiotic‑resistant, UTI-causing strains, offering insights to engineer potent phages on Earth; findings published in PLOS Biology.

via ScienceAlert|
#antibiotic-resistance#bacteriophage#e-coli
Four advances aim to outpace antibiotic resistance and reboot modern medicine
science-tech1 month ago

Four advances aim to outpace antibiotic resistance and reboot modern medicine

Antibiotic resistance threatens a century of medical progress, but four broad advances are reshaping the landscape: faster, on-site diagnostics; expansion beyond traditional antibiotics through nontraditional therapies (including bacteriophages and microbiome-based approaches and CRISPR antimicrobials); recognizing resistance spreads across ecosystems with One Health approaches; and policy reforms to incentivize antibiotic development, aiming to diagnose earlier, widen treatment options, and safeguard medicines for the future.

via The Conversation|
#antibiotic-resistance#bacteriophage-therapy#diagnostics
Space-born phages gain edge against Earth bacteria
health1 month ago

Space-born phages gain edge against Earth bacteria

Scientists studied bacteria and their viruses aboard the International Space Station and found that microgravity drives phages to evolve in ways that boost their ability to infect bacteria. When space-adapted phages were returned to Earth, they showed increased activity against common, drug-resistant E. coli strains, suggesting space-driven mutations could help optimize phage therapies for infections on Earth, though the practical costs of space-based research remain a consideration.

via Live Science|
#antibiotic-resistance#health#microgravity
LA uncovers novel XDR Shigella in two independent cases
health1 month ago

LA uncovers novel XDR Shigella in two independent cases

A novel extensively drug-resistant Shigella sonnei strain was identified in two unrelated Los Angeles patients, one a 34-year-old man with advanced HIV and substance abuse and the other a 33-year-old immunocompromised woman with high-grade B-cell lymphoma. The isolates carried resistance genes blaDHA-1 and blaCTX-M-15, suggesting dual beta-lactam resistance and raising concern about wider spread and treatment challenges. Both patients required intravenous carbapenems, underscoring the need for close genomic surveillance and monitoring for broader community transmission.

via CIDRAP|
#antibiotic-resistance#ctx-m-15#health