LA uncovers novel XDR Shigella in two independent cases
A novel extensively drug-resistant Shigella sonnei strain was identified in two unrelated Los Angeles patients, one a 34-year-old man with advanced HIV and substance abuse and the other a 33-year-old immunocompromised woman with high-grade B-cell lymphoma. The isolates carried resistance genes blaDHA-1 and blaCTX-M-15, suggesting dual beta-lactam resistance and raising concern about wider spread and treatment challenges. Both patients required intravenous carbapenems, underscoring the need for close genomic surveillance and monitoring for broader community transmission.