Tag

Tau

All articles tagged with #tau

science13 days ago•5 min saved

Brain Cells with a Built-In Defense Against Dementia Found

A CRISPR-based screen in human neurons with disease-causing tau mutations identified the CRL5SOCS4 protein complex as a key driver of tau protein degradation, helping some brain cells resist toxic tau clumps and dementia. Findings align with brain atlas data showing higher CRL5SOCS4 expression correlates with cell survival, and researchers note mitochondrial dysfunction can increase pathogenic tau fragments. Potential therapies include boosting CRL5SOCS4 activity or protecting proteasomes to enhance tau clearance.

via ScienceAlert|

#alzheimers-disease #crispr #mitochondria

neuroscience23 days ago•8 min saved

Boosting NAD+ Rewires RNA Splicing to Undo Alzheimer's Brain Damage

An international study shows boosting NAD+ levels can protect and reverse Alzheimer's-related brain damage by activating an EVA1C-regulated RNA-splicing pathway, correcting mis-splicing, improving hundreds of genes tied to brain health, and restoring memory in worm and mouse models with supporting human brain data—hinting at a new therapeutic approach beyond targeting plaques or tangles.

via SciTechDaily|

#alzheimers-disease #eva1c #nad

sports1 month ago•2 min saved

Volkanovski-Lopes Rematch Secured as Weigh-In Controversy Impacts Road to UFC Final

At UFC 325 weigh-ins, Alexander Volkanovski (144.5 lb) and Diego Lopes (145 lb) made the featherweight limit for their title rematch, with Dan Hooker vs. Benoit Saint Denis also hitting the non-title limit (155.75). Aaron Tau missed weight in a late, box-referenced weigh-in, initially showing 122.5 before re-weighing at 129, which led to the cancellation of his Road to UFC Flyweight Final against Namsrai Batbayar. The rest of the card remained on schedule.

via MMA Fighting|

#lopes #sports #tau

science1 month ago•4 min saved

OTULIN: A Master Switch for Tau Points to a New Alzheimer’s Target

Researchers show the enzyme OTULIN acts as a master regulator of tau production in neurons: blocking OTULIN reduced tau levels and removing its gene even halted tau synthesis, while RNA analysis revealed widespread changes in gene activity, notably in inflammatory pathways; the findings open a potential new route to slow brain aging and Alzheimer's, but safety concerns remain since OTULIN and tau have essential functions and much more research is needed.

via ScienceAlert|

#alzheimers-disease #inflammation #neurodegeneration

science1 month ago•6 min saved

OTULIN Emerges as Master Regulator to Rewire Brain Aging

A study identifies OTULIN as a high-level regulator in neurons that controls gene expression and RNA metabolism, shaping tau biology in brain aging and Alzheimer's disease. Partial inhibition of OTULIN reduced pathogenic tau, while CRISPR deletion nearly abolished tau by silencing MAPT mRNA, but also caused widespread transcriptome changes. The work suggests therapies could recalibrate neuronal regulatory networks to counter aging and neurodegeneration, though complete loss of OTULIN would be harmful and requires precise tuning.

via The Debrief|

#alzheimers-disease #brain-aging #gene-expression

science1 month ago•7 min saved

OTULIN Regulates Tau in Neurons, Opening Alzheimer’s Therapy Avenues

Researchers at the University of New Mexico found that OTULIN, an enzyme known for immune regulation, also controls tau production in neurons. By inhibiting OTULIN with a small molecule or knocking out the OTULIN gene, they stopped new tau formation and cleared existing tau in human neuron models, suggesting a novel target for treating Alzheimer’s disease and related tauopathies. The findings also linked OTULIN to RNA metabolism and inflammatory pathways, and researchers note the need to study effects across different brain cell types before pursuing therapies.

via SciTechDaily|

#alzheimers-disease #brain-aging #neurodegenerative-diseases

gaming7 months ago•1 min saved

Warframe Announces 'The Old Peace' Expansion and New Devil-Themed Warframe

Warframe will receive a new narrative chapter 'The Old Peace' in 2025, exploring Tau's past and the war between the Orokin and Dax Anarch Warriors, followed by the Tau-focused chapter in 2026. The update will include new storylines, character models, a new ultimate ability, and other improvements, with additional updates and a closed beta arriving later this year.

via Wccftech|

#gaming #narrative-chapter #tau

gaming7 months ago•3 min saved

Warframe Unveils Year of Demon-Inspired Updates and Lore Expansions

Warframe announced its upcoming year of updates including a major quest called The Old Peace, a cinematic tutorial on Mods, new characters, enemy factions, graphical remasters, collaborations, and a planned narrative chapter Tau for 2026, with various seasonal and special content releases throughout 2023 and 2024.

via Eurogamer|

#cinematic-tutorial #gaming #tau

health2 years ago•3 min saved

Gut Bacteria as Early Warning for Alzheimer's Disease

Certain microbes in the gut microbiome are more common in those with very early signs of Alzheimer's disease, pointing to a potential new method of diagnosis for a disease that affects millions worldwide. The researchers found distinct differences in the gut microbiome profiles of older people with and without signs of preclinical Alzheimer's. Analyzing a person's gut microbiome to assess their risk of developing the disease would offer a non-invasive, more accessible way of identifying those at risk of developing Alzheimer's at an earlier stage, allowing them more time to plan and prepare for the future.

via ScienceAlert|

#alzheimers #amyloid-beta #diagnosis

health2 years ago•19 min saved

Using Blood Biomarkers for Alzheimer's Diagnosis and Treatment.

Researchers have identified several blood biomarkers that can aid in the diagnosis and monitoring of Alzheimer's disease, including CSF biomarkers such as Aβ42/Aβ40 and p-tau217, as well as plasma biomarkers such as β-amyloid 42/40 and phospho-tau217. These biomarkers have been shown to correlate with amyloid and tau pathology in the brain, and can be used in clinical practice and trials to track disease progression and response to treatment.

via Nature.com|

#alzheimers-disease #biomarkers #clinical-trials

health2 years ago•5 min saved

Sleeping Pill Reduces Alzheimer's Proteins, Study Shows

A small study suggests that the insomnia medication suvorexant could potentially reduce Alzheimer’s proteins in the brain, but more research is needed to confirm its effectiveness in preventing or slowing the disease. Participants who took a higher dose of the drug experienced a significant drop in amyloid and hyperphosphorylated tau levels. Sleep disturbances can be an early sign of Alzheimer’s disease, and poor sleep accelerates harmful changes to the brain.

via SciTechDaily|

#alzheimers-disease #amyloid #health

health2 years ago•3 min saved

Sleeping Pill May Reduce Alzheimer's Proteins

A new study has found that using sleeping pills to get some shut-eye could reduce the build-up of toxic clumps of proteins in fluid that washes the brain clean every night. Researchers found people who took suvorexant, a common treatment for insomnia, for two nights at a sleep clinic experienced a slight drop in two proteins, amyloid-beta and tau, that pile up in Alzheimer's disease. Sleep disturbances can be an early warning sign of Alzheimer's disease that precedes other symptoms, such as memory loss and cognitive decline.

via ScienceAlert|

#alzheimers-disease #amyloid-beta #health

health2 years ago•4 min saved

"Sleeping Pill and Bedtime Trick Show Promise in Reducing Alzheimer's Risk"

A small study conducted by researchers at the University of Washington in St Louis, Missouri, found that a common sleeping pill, suvorexant, can reduce the levels of Alzheimer's linked proteins in the brain. Participants who took the highest dose had amyloid levels that were up to a fifth lower than other participants in their spinal fluid by the next morning. However, scientists are not urging people to start taking the pills every night, saying much more extensive research is needed to back up the results.

via Daily Mail|

#alzheimers #amyloid #health