All articles tagged with #potential treatments
Originally Published 3 months ago — by IFLScience
Excessive alcohol use impairs liver regeneration by causing splicing errors in key proteins, trapping damaged cells in a non-functional state even after sobriety, but understanding this mechanism opens avenues for new treatments.
Originally Published 2 years ago — by Neuroscience News
Researchers have provided the first high-resolution images and structural details of LINE-1, an ancient genetic element that inserts itself into the human genome and is implicated in diseases such as cancer, autoimmune disorders, neurodegeneration, and aging. This study sheds light on a small part of the "dark genome" and offers a foundation for potential treatments targeting LINE-1 related diseases.
Originally Published 2 years ago — by Nature.com
Researchers are exploring the use of CRISPR gene editing to develop new treatments for Alzheimer's disease caused by genetic mutations. While current treatments for Alzheimer's can slow the progression of the disease, they often do not benefit those in later stages or with specific genetic variants. CRISPR therapies have the potential to be a one-time cure, but there are challenges in applying this technology to the complex condition of Alzheimer's. Studies have shown promising results in mice, targeting genes such as APOE and PSEN1, but further research and clinical trials are needed to ensure safety and efficacy. Researchers hope that one day CRISPR gene editing could be combined with other therapies to provide personalized treatments for Alzheimer's patients.
Originally Published 2 years ago — by Livescience.com
Researchers are exploring the use of vaccines as potential treatments for Alzheimer's disease. The current approach focuses on targeting beta-amyloid plaques, but drugs that remove these plaques have not shown significant impact on the disease. Some researchers propose that Alzheimer's may result from a poorly regulated immune response to infection, leading to inflammation and the overproduction of beta-amyloid. Vaccines could potentially retrain the immune system to fight the disease by stimulating the cells that clear beta-amyloid and suppressing the immune cascade responsible for its release. Vaccines such as Bacille Calmette-Guérin (BCG) and Protollin are being tested in clinical trials, while other companies are developing vaccines that directly target beta-amyloid. The safety and effectiveness of these vaccines are still being investigated, but they could potentially make Alzheimer's treatment more accessible and affordable compared to existing antibody therapies.