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Geneticsneuroscience

All articles tagged with #geneticsneuroscience

geneticsneuroscience2 years ago•4 min saved

"Unlocking Disease Treatment Potential: Unveiling the Structure of LINE-1 Reverse Transcriptase"

Researchers have provided the first high-resolution images and structural details of LINE-1, an ancient genetic element that inserts itself into the human genome and is implicated in diseases such as cancer, autoimmune disorders, neurodegeneration, and aging. This study sheds light on a small part of the "dark genome" and offers a foundation for potential treatments targeting LINE-1 related diseases.

via Neuroscience News|

#dark-genome #disease #genetic-element

geneticsneuroscience2 years ago•5 min saved

Decoding the Genetic Roots of Neurodevelopmental Disorders

Researchers have identified three novel genes that contribute to neurodevelopmental disorders by impacting the spliceosome, a protein complex responsible for gene splicing. Through genomic sequencing, phenotyping, and modeling in fly and stem cells, the study revealed the malfunction of these genes in conditions such as developmental delay, intellectual disability, and autism. This breakthrough provides a deeper understanding of the genetic mechanisms behind neurodevelopmental disorders and opens up potential therapeutic targets for future treatments.

via Neuroscience News|

#brain-development #gene-splicing #genetic-architecture