All articles tagged with #line 1
A recent study uncovers how the 'jumping gene' LINE-1 hijacks cell division processes by forming condensates with proteins to enter the nucleus and copy itself, providing insights into genome evolution and potential therapeutic targets.
Researchers have made a breakthrough in understanding LINE-1, an ancient genetic element found in the "dark genome" that is associated with various diseases. The study provides high-resolution images and structural details of LINE-1 and its reverse transcriptase enzyme, revealing similarities to HIV-1 reverse transcriptase. This discovery opens up potential pathways for targeted drug development and treatment of diseases such as cancer, autoimmune disorders, neurodegeneration, and aging.
Researchers have provided the first high-resolution images and structural details of LINE-1, an ancient genetic element that inserts itself into the human genome and is implicated in diseases such as cancer, autoimmune disorders, neurodegeneration, and aging. This study sheds light on a small part of the "dark genome" and offers a foundation for potential treatments targeting LINE-1 related diseases.
Researchers have discovered that ancient retroviruses, specifically LINE-1, play a complex role in early embryonic development. Through computational analyses, scientists found a cluster of cells in the embryo that exhibited DNA damage and precursors to apoptosis, which they named "REjects." However, surviving cells expressed HERVH, another retrovirus that suppresses LINE-1 and protects pluripotent cells from harm. The study sheds light on the intricate interactions within the genome and may have implications for regenerative medicine and understanding early pregnancy losses.