All articles tagged with #neurogenesis
A study of 38 postmortem brains links exceptional memory in superagers to higher hippocampal neurogenesis, finding roughly twice as many immature neurons as in typical older adults; Alzheimer's groups show reduced immature neurons, while genetic data point to stronger synaptic plasticity and BDNF activity in superagers, suggesting neurogenesis as a driver of cognitive resilience and a potential therapeutic target.
A Nature-published study from Northwestern and the University of Illinois Chicago finds that adults 80+ who are labeled 'super-agers' generate about twice as many immature hippocampal neurons as typical older adults, suggesting a genetic/molecular basis for preserved cognition and notable brain plasticity, though the small sample size and brain variability warrant cautious interpretation.
New Nature study finds that older adults with healthy cognition, including 'super agers', continue to produce immature neurons in the hippocampus at higher levels than those with cognitive decline, suggesting persistent neurogenesis may support memory; the neuron fraction is tiny (~0.01%), and the small sample sizes mean results should be interpreted cautiously; researchers hope to harness this process to develop therapies that boost neurogenesis in aging and Alzheimer's.
A Nature study finds that super-agers (80+) have roughly twice as many new neurons in the hippocampus as older adults with normal memory, and about 2.5 times more than people with Alzheimer’s, suggesting adult neurogenesis may help explain their exceptional memory and cognitive resilience.
A study of self-described “SuperAgers”—people over 80 with exceptional memory—shows they have more newly formed neurons and a hippocampal environment that supports neurogenesis, along with thicker attention-related brain regions and fewer tau tangles than typical aging. Using multiomic single-cell sequencing across donor brains, researchers found astrocytes and CA1 neurons drive memory retention, suggesting that a combination of genetics and brain-healthy lifestyle supports sustained cognition into advanced age.
A Florida Atlantic University study shows boosting the muscle-derived protein Cathepsin B in mice with Alzheimer’s preserves memory and brain cell growth, even without reducing amyloid plaques, suggesting muscle signaling to the brain could be a new avenue for neurodegenerative therapies—though benefits did not extend to healthy mice and human relevance remains to be proven.
Shrews reduce brain size by about 30% in winter to conserve energy and regrow it in spring; new research traces the genetic basis of Dehnel's phenomenon, showing upregulated brain-formation genes, VEGFA, DNA repair and longevity pathways, and water-regulation changes that imply reversible brain-volume loss rather than neuron death—offering clues for neurodegenerative disease research.
Johns Hopkins researchers found that loss of the brain enzyme cystathionine γ-lyase (CSE), which makes hydrogen sulfide, causes memory loss and Alzheimer’s-like brain damage in mice, highlighting CSE as a potential drug target to boost brain health and slow neurodegeneration.
Exercise benefits brain health by releasing substances into the bloodstream, particularly vesicles that promote neurogenesis, and these effects may be transferable between individuals, as shown in mouse studies. This research suggests a complex, multi-pathway process behind exercise's positive impact on the brain.
The article discusses how transcriptional interference mechanisms ensure that each ant olfactory neuron expresses only one olfactory receptor, highlighting the complex regulation of receptor gene expression during neurogenesis.
Scientists have discovered neural progenitor cells in the adult human hippocampus, previously thought to only exist in childhood, using machine learning techniques. This finding suggests ongoing neuron formation in adults, opening new possibilities for treating neurodegenerative diseases.
A new study confirms that the human hippocampus continues to generate new neurons throughout adulthood, particularly in the dentate gyrus, which is crucial for memory and emotion regulation. Using RNA analysis and machine learning, researchers found ongoing neurogenesis across different ages, with potential implications for understanding brain aging, learning, and treating neurodegenerative diseases.
A study from Karolinska Institute confirms that the human hippocampus continues producing new neurons into late adulthood, with neural progenitor cells present up to age 78, potentially opening avenues for regenerative therapies for brain disorders.
A new study provides strong evidence that adult humans can generate new neurons in the hippocampus, potentially ending decades of debate and opening new avenues for understanding brain plasticity, learning, and recovery from injury.
Recent research from Sweden demonstrates that adult human brains continue to generate new neurons, particularly in the hippocampus, challenging the long-held belief that brain cell growth stops after childhood. The study analyzed over 400,000 individual cell nuclei, finding neural progenitor cells actively dividing in adults, which could have implications for treating neurological conditions and understanding brain plasticity. However, the extent and pattern of neurogenesis vary among individuals, raising further questions about its role in health and disease.