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Liquid Biopsy

All articles tagged with #liquid biopsy

Cancer’s Hidden Barcode: OncRNA Signatures Map Tumor Identity and Treatment Response
science1 month ago

Cancer’s Hidden Barcode: OncRNA Signatures Map Tumor Identity and Treatment Response

Researchers mapped hundreds of thousands of cancer-specific small RNAs (oncRNAs) that act as digital barcodes to identify cancer type, subtype, and aggressiveness. Many oncRNAs are secreted into blood, enabling a simple serum test to monitor treatment response and predict survival. The work blended large-scale genome analysis, machine learning, mouse experiments, and data from nearly 200 breast cancer patients, finding about 5% of oncRNAs can drive tumor growth. The discovery points to a new, blood-based approach for real-time cancer monitoring and personalized therapy, with ongoing development in collaboration with Exai Bio.

Blood test flags effective breast cancer therapies before treatment starts
health1 month ago

Blood test flags effective breast cancer therapies before treatment starts

A London study shows a simple liquid biopsy measuring circulating tumour DNA (ctDNA) in advanced breast cancer can predict treatment response before starting therapy and after one cycle. In 167 patients, lower ctDNA levels were associated with better outcomes, suggesting this test could guide personalized treatment and spare ineffective drugs, with trials exploring adaptive strategies and newer therapies.

Advances in Blood Tests Promise Early Detection and Improved Cancer Outcomes
health2 months ago

Advances in Blood Tests Promise Early Detection and Improved Cancer Outcomes

New blood tests capable of detecting multiple cancers simultaneously show promise for earlier diagnosis and improved cancer care, but currently face challenges such as high false-positive rates, lack of standardization, and integration into clinical practice. Experts believe these tests will improve over time and could revolutionize cancer diagnostics, though more research and validation are needed.

Revolutionary Blood Tests Transforming Cancer Detection and Care in the NHS
health9 months ago

Revolutionary Blood Tests Transforming Cancer Detection and Care in the NHS

Scientists highlight that small health issues like persistent cough, breathlessness, and unexplained weight loss can be early signs of lung cancer. NHS England is introducing a groundbreaking liquid biopsy blood test for faster, personalized cancer diagnosis, initially for lung and breast cancers, which could significantly improve early detection and treatment outcomes.

Breakthrough Blood Test Revolutionizes Rapid Cancer Detection
health1 year ago

Breakthrough Blood Test Revolutionizes Rapid Cancer Detection

Researchers at the University of Rochester have developed a new method called "catch and display for liquid biopsy" (CAD-LB) that uses ultrathin membranes to capture extracellular vesicles (EVs) from a single drop of blood. This method simplifies the process of identifying EVs, which carry important biomarkers, making it faster and more cost-effective for cancer diagnosis and monitoring treatment progress. The technique also shows potential for detecting immune proteins, aiding in the selection of personalized immunotherapies.

"New Blood Test Achieves 100% Accuracy in Predicting Breast Cancer Relapse"
health1 year ago

"New Blood Test Achieves 100% Accuracy in Predicting Breast Cancer Relapse"

A new ultra-sensitive blood test developed by researchers at the Institute of Cancer Research in London can predict the recurrence of breast cancer years before it appears on scans, with 100% accuracy. The test detects circulating tumor DNA (ctDNA) using whole genome sequencing, identifying up to 1,800 mutations. This breakthrough could enable earlier treatment and better long-term monitoring for patients at high risk of relapse.

"Breakthrough Blood Test Predicts Breast Cancer Recurrence with 100% Accuracy"
health1 year ago

"Breakthrough Blood Test Predicts Breast Cancer Recurrence with 100% Accuracy"

A new blood test using whole genome sequencing can predict the risk of breast cancer returning up to three years before tumors appear on scans. This breakthrough, presented at the American Society of Clinical Oncology annual meeting, could help identify which women need preventive therapy and improve early treatment, significantly increasing the chances of beating the disease. Researchers found the test to be highly sensitive, accurately predicting relapse in all trial patients who later experienced recurrence.

"New Blood Test Predicts Breast Cancer Recurrence Years in Advance"
health1 year ago

"New Blood Test Predicts Breast Cancer Recurrence Years in Advance"

A new ultra-sensitive blood test can predict the return of breast cancer up to three and a half years before it shows up on scans, allowing for earlier treatment and potentially saving many lives. The test, developed by researchers at the Institute of Cancer Research in London, detects circulating tumor DNA and has shown 100% accuracy in trials. This advancement could significantly improve post-treatment monitoring and outcomes for breast cancer patients.

"Advancements in Early Detection of Pancreatic Cancer"
health-medicine1 year ago

"Advancements in Early Detection of Pancreatic Cancer"

Pancreatic cancer, the third leading cause of cancer deaths in the US, lacks a standard early detection test, but researchers are exploring blood-based liquid biopsy tests to spot early cases. A study presented at the American Association for Cancer Research detailed a liquid biopsy test that detected 97% of stage I and II pancreatic cancers in volunteers. While there's excitement about the potential of these tests, more research is needed before they can be used clinically. Early detection could significantly improve survival rates for pancreatic cancer, which is often diagnosed at advanced stages, and developing a reliable early detection test could dramatically change the landscape for patients.

Revolutionary Breakthrough: Breast Milk as a Game-Changer in Early Breast Cancer Detection
health2 years ago

Revolutionary Breakthrough: Breast Milk as a Game-Changer in Early Breast Cancer Detection

Breast milk from breast cancer patients has been found to contain circulating tumor DNA (ctDNA) that can be detected through a liquid biopsy, according to a study published in Cancer Discovery. Researchers at the Vall d'Hebron University Hospital in Barcelona, Spain, analyzed breast milk samples from breast cancer patients and found tumor mutations in 87% of cases, compared to only 8% in blood samples. The team has developed a genomic panel using next-generation sequencing that shows promise for early detection of breast cancer in women under 45 years old. The researchers plan to validate the breast milk liquid biopsy as a screening method in a larger clinical trial.