All articles tagged with #alphagenome
At the Undiagnosed Hackathon, DeepMind's AlphaGenome was used to predict how noncoding DNA mutations affect gene activity, helping researchers tie variants to 29 undiagnosed conditions and illustrating AI’s potential to illuminate the genome’s dark matter for hundreds of millions with undiagnosed rare diseases.
DeepMind's AlphaGenome, described in Nature, can analyze up to about 1 megabase of DNA at a time—roughly a million letters—outperforming prior AI models in 25 of 26 tests and predicting thousands of functional genomic tracks along with nearly 6,000 human genetic signals. Trained on both human and mouse genomes, it aims to illuminate how coding and non-coding regions interact and regulate genes. While praised as a milestone, experts caution that data quality and standardization remain limiting factors; the model could help diagnose rare genetic diseases, identify cancer mutations, and reveal drug targets, but it isn’t a complete solution yet.
Google DeepMind unveils AlphaGenome, an AI that predicts how genetic mutations affect gene regulation across tissues, helping scientists pinpoint disease-driving variants and potentially guide new therapies; trained on public human and mouse data, it analyzes large DNA segments to map essential regulatory elements and their cell-type effects, with early praise from researchers but noting that real-world validation remains ongoing.