Tag

Recombination

All articles tagged with #recombination

science1 month ago•43 min saved

Common regulatory variant in meiosis genes links crossover control to maternal aneuploidy risk

A large IVF-PGT analysis (139,416 embryos, 22,850 parental sets) maps crossovers and meiotic aneuploidy at scale and finds a common non-coding haplotype in SMC1B that associates with both lower maternal recombination and higher maternal meiotic aneuploidy, supported by functional assays and TWAS implicating C14orf39 and ubiquitin ligases CCNB1IP1/RNF212. SNP heritability for aneuploidy is negligible, suggesting environmental and rare-variant effects, while an inverse link between recombination rate and aneuploidy emerges. Evolutionary modelling suggests the risk allele is ancient and common, with complex fitness dynamics that can maintain it in populations. The work reveals a shared genetic basis for recombination and aneuploidy, with implications for fertility and genome evolution.

via Nature|

#aneuploidy #c14orf39 #meiosis

biology2 months ago•39 min saved

Widespread Gene Sweeps in Human Gut Microbiomes

The study reveals that gene-specific selective sweeps are widespread across human gut microbiomes, driven by homologous recombination and horizontal gene transfer, with implications for understanding microbial adaptation to host diets and lifestyles worldwide.

via Nature|

#biology #horizontal-gene-transfer #human-gut-microbiome

science3 months ago•12 min saved

AI Unveils Genetic 'Time Capsules' Driving Mammal Speciation

The article discusses the discovery of an ancient recombination desert acting as a supergene that influences speciation in placental mammals, highlighting the role of genomic architecture and introgression in evolutionary processes.

via Nature|

#genomics #placental-mammals #recombination

biology5 months ago•76 min saved

ZMM Proteins and Holliday Junctions Ensure Accurate Meiotic Crossovers

The study reveals a feedback mechanism where double Holliday junctions (dHJs) and ZMM proteins work together to maintain the synaptonemal complex (SC) during meiosis, ensuring crossover formation and suppressing new DNA double-strand breaks, thereby coordinating meiotic progression and crossover assurance.

via Nature|

#biology #dhjs #meiosis

science8 months ago•5 min saved

Unveiling the Universe's First Light

Light in the universe's early moments was initially trapped in a dense, hot environment after the Big Bang, but around 380,000 years later, cooling allowed photons to escape, creating the cosmic microwave background and marking the universe's first light, which paved the way for star and galaxy formation.

via The Daily Galaxy|

#big-bang #cosmic-microwave-background #light

health8 months ago•6 min saved

New COVID Variant NB.1.8.1 Sparks Global Surge Concerns

The Nimbus COVID-19 variant, a recombinant strain under monitoring, has been detected in multiple countries and may contribute to a summer surge of cases due to its increased transmissibility and immune evasion, though it is not yet linked to more severe illness. Current vaccines remain effective against it, but concerns about vaccine access and evolving guidelines could impact future protection efforts.

via Salon.com|

#covid-19 #health #nimbus-variant

science2 years ago•82 min saved

Insights into SARS-CoV-2 evolution, treatment, and prevalence in children.

This review article explores the mechanisms that generate genetic variation in SARS-CoV-2, underlying the within-host and population-level processes that underpin these events. The article examines the selective forces that likely drove the evolution of higher transmissibility and, in some cases, higher severity during the first year of the pandemic and the role of antigenic evolution during the second and third years, together with the implications of immune escape and reinfections, and the increasing evidence for and potential relevance of recombination. The article also evaluates uncertainties and outlines scenarios for the possible future evolutionary trajectories of SARS-CoV-2.

via Nature.com|

#evolution #mutation #recombination