Tag

Aneuploidy

All articles tagged with #aneuploidy

science2 years ago•2 min saved

"Discovery of Prehistoric Individual with Absent X Chromosomes from Ancient DNA Analysis"

Researchers have identified the earliest known cases of two genetic disorders, Turner syndrome and Jacob's syndrome, in prehistoric individuals using a new technique to measure the number of chromosomes in ancient DNA. The study also revealed three people with Klinefelter syndrome and an infant with Down syndrome from different time periods. This method could provide insights into how perceptions of gender identity have evolved over time and may be applied to analyze incomplete ancient DNA in archaeological remains.

via IFLScience|

#ancient-dna #aneuploidy #genetic-disorders

health2 years ago•4 min saved

"Breakthrough Cancer Treatment Unveiled by Yale Researchers"

Yale researchers have discovered that cancer cells with extra chromosomes rely on those additional chromosomes for tumor growth, and removing them halts tumor formation. The study, published in the journal Science, suggests that selectively targeting these extra chromosomes may offer a new avenue for treating cancer. The researchers used the gene-engineering technique CRISPR to develop a new approach called ReDACT, which successfully eliminated aneuploidy in melanoma, gastric cancer, and ovarian cell lines. The findings indicate that aneuploidy may function as a therapeutic target for cancer, potentially allowing for targeted treatment while minimizing harm to normal cells. Further research is needed before this approach can be tested in clinical trials.

via SciTechDaily|

#aneuploidy #cancer-treatment #crispr