Tag

Protein Complex

All articles tagged with #protein complex

science1 year ago•4 min saved

Crucial Protein and Enhancer Module Unveil Neural Development Secrets

Researchers at the Wistar Institute have identified the protein subunit INST10 as crucial for guiding pluripotent stem cells to develop into neural cells, maintaining their identity and preventing them from becoming other cell types. This discovery sheds light on the molecular processes of neurogenesis and links mutations in the Integrator protein complex to neurodevelopmental disorders, offering new insights into early neural development.

via Neuroscience News|

#cell-identity #neurodevelopment #neuroscience

science-and-technology2 years ago•6 min saved

"Shapeshifting DNA-Repair Protein Complex Unveiled: Insights from Georgia State Researchers"

Researchers have discovered that the protein complex TFIIH, which plays critical roles in transcription and DNA repair, is a shapeshifter that reconfigures itself to meet the demands of each task. By conducting molecular dynamics simulations, the team found that TFIIH undergoes structural changes to carry out its functions. Understanding the inner workings of TFIIH is crucial for understanding genetic disorders caused by mutations and could lead to the development of therapeutic strategies. The research provides insights into the mechanical dynamics of TFIIH and its role in DNA repair and transcription initiation.

via Phys.org|

#dna-repair #genetic-disorders #molecular-dynamics-simulations

neuroscience2 years ago•3 min saved

Uncovering the Mystery of mRNA Delivery in Brain Cells with Neuroscience Breakthrough.

Collaborative efforts from teams at the MPI Institutes have led to the discovery of a protein complex, named FERRY, which links mRNA to intra-cellular carriers and transports it exactly where it’s needed within neurons. The discovery may lead to a better understanding of neurological disorders caused by FERRY malfunction and possibly to new medical targets. The researchers have identified the structure and role of FERRY, which interacts directly with mRNA and holds it onto Early Endosomes (EEs), which become logistic carriers for mRNA transport and distribution in brain cells.

via SciTechDaily|

#ferry #mrna #neurological-disorders

health2 years ago•3 min saved

"Thunder God Vine: A Natural Remedy for Arthritis"

Researchers at Osaka University have identified a protein complex, COMMD3/8, that plays a role in accelerating rheumatoid arthritis and other autoimmune diseases. They discovered that celastrol, a compound extracted from the root of a medicinal plant commonly referred to as the “Thunder God vine”, is an effective inhibitor of the COMMD3/8 complex. Celastrol binds to COMMD3 covalently and prevents the formation of the COMMD3/8 complex, thus impairing the antibody response and blocking the progression of rheumatoid arthritis in a mouse model.

via SciTechDaily|

#autoimmunity #celastrol #health

science2 years ago•3 min saved

The Quantum Mysteries of Photosynthesis Unveiled.

Researchers at the US Department of Energy's SLAC National Accelerator Laboratory have captured an image of the atoms inside cyanobacteria undergoing photosynthesis just as the tiny organism released oxygen. The team used X-ray lasers to image the different steps in the reaction and discovered a previously unknown step in the process. The research could potentially lead to the creation of new fuels that use sunlight to make clean energy.

via The Register|

#clean-energy #cyanobacteria #photosynthesis

science2 years ago•3 min saved

Unlocking the Mysteries of Photosynthesis: New Discoveries Made.

Researchers at the SLAC National Accelerator Laboratory and Lawrence Berkeley National Laboratory have observed in atomic detail how Photosystem II, a protein complex found in plants, undergoes a transformation that leads to the loss of an extra oxygen atom. The discoveries will help provide a roadmap for optimizing clean energy sources. The team believes the results will help them “develop artificial photosynthetic systems that mimic photosynthesis to harvest natural sunlight to convert carbon dioxide into hydrogen and carbon-based fuels.”

via Engadget|

#clean-energy #oxygen #photosynthesis