All articles tagged with #lifespan extension
A recent study suggests that Covid mRNA vaccines may boost the immune response in cancer patients, significantly increasing their median survival time and potentially revolutionizing cancer treatment by repurposing existing vaccines to enhance immune system activation, though further research is needed to confirm causation.
A study from UC Berkeley found that a combination of oxytocin and A5i extended the lifespan of male mice by up to 73%, but had no effect on females, highlighting sex differences in aging and potential for targeted therapies, with implications for human aging research.
A study found that combining oxytocin with an Alk5 inhibitor significantly extended lifespan and improved health in aged male mice by reducing biological noise and promoting tissue rejuvenation, with sex-specific differences observed as females did not experience the same benefits. The treatment shows promise for human anti-aging therapies, given the existing approval and clinical trials of the components.
Reducing intake of the amino acid isoleucine in mice extended their lifespan by up to 33%, improved health markers, and reduced frailty, suggesting potential anti-aging benefits for humans, though further research is needed.
Recent Japanese walking trends, involving alternating fast and slow paces, may add up to 7 years to life expectancy by reducing age-related health risks, and are a moderate alternative to high-intensity workouts like HIIT, making exercise more accessible and sustainable for many.
The blood pressure drug rilmenidine has been shown to extend lifespan and slow aging in worms and mice by mimicking caloric restriction effects, with potential implications for human health and aging, pending further research.
Research from Emory University suggests that psilocybin, the active compound in psychedelic mushrooms, may delay aging and extend lifespan by improving cellular health and reducing oxidative stress, with potential implications for anti-aging therapies and mental health benefits.
A meta-analysis suggests that rapamycin may extend lifespan in animals similarly to dietary restrictions, unlike metformin, but human trials are needed to confirm its effects and safety for longevity in people.
European scientists have found that a combination of two cancer drugs, rapamycin and trametinib, can extend mice lifespans by up to 30% and improve their health, with potential implications for human aging and age-related diseases.
Scientists in Europe found that a cocktail of two cancer drugs, rapamycin and trametinib, extended mice lifespans by about 30%, improved health markers, and delayed age-related diseases, suggesting potential for human anti-aging therapies, though more research is needed.
San Francisco-based company Loyal has received conditional approval from the FDA for its anti-aging drug, LOY-001, designed to extend the lifespan of large- and giant-breed dogs. The drug aims to reduce the growth-promoting hormone IGF-1 in adult dogs, addressing the shorter lifespans of larger breeds. If approved, LOY-001 could be available as early as 2026, offering the potential for an extended and healthier life for dogs over the age of 7 and weighing more than 40 pounds. Loyal must still conduct further studies and meet FDA criteria for full approval.
Researchers from Eötvös Loránd University have made a breakthrough in understanding the aging process by studying transposable elements (TEs) in DNA. They identified the Piwi-piRNA pathway, which controls the activity of TEs, and found that managing TEs can extend lifespan. By downregulating TEs in worms, the researchers observed slower aging and a significant increase in lifespan. This discovery has implications for medical and biological research, potentially leading to the development of methods to extend human life and improve health in later years. Additionally, the researchers discovered epigenetic changes in the DNA of aging worms, which could potentially be used as a biological clock to determine age.
Researchers at Duke Health have discovered that surgically joining the circulatory systems of young and old mice, known as heterochronic parabiosis, can slow cellular aging and extend the lifespan of older mice by up to 10%. The longer the mice shared circulation, the more enduring the anti-aging effects. The study suggests that young blood's components could potentially be isolated as therapies to rejuvenate the body and add years to an older individual's life. However, the study was conducted on mice, and the specific factors in young blood that drive the anti-aging effects are still unknown.
Scientists are actively researching ways to slow down the aging process and extend human lifespans. With increasing investment and experimentation by tech billionaires, it is possible that by 2100, people may typically live to be 100 years old. However, there is still uncertainty about the limits of human lifespan extension.
Researchers have discovered that controlling the activity of transposable elements (TEs), which are mobile DNA elements, can extend lifespan in worms. By downregulating specific TEs and strengthening the Piwi-piRNA pathway, the worms showed signs of aging slower and lived significantly longer. The study also revealed epigenetic changes in the DNA of the worms as they aged, which could potentially be used as a biological clock to determine age from DNA. This breakthrough in understanding the role of TEs and their control pathways opens up possibilities for developing methods to extend life and improve health in later years.