The blood pressure drug rilmenidine has been shown to extend lifespan and slow aging in worms and mice by mimicking caloric restriction effects, with potential implications for human health and aging, pending further research.
A meta-analysis suggests that rapamycin may extend lifespan in animals similarly to dietary restrictions, unlike metformin, but human trials are needed to confirm its effects and safety for longevity in people.
Researchers from the University of Texas at Austin have discovered a drug, PEG-MTAP, that shows promise in enhancing the immune system's ability to fight tumors. In animal studies involving melanoma, bladder cancer, leukemia, and colon cancer, the drug hindered tumor growth, prolonged life, and amplified the effectiveness of immunotherapy. The drug targets the 9p21 DNA segment deletion, which is prevalent in many cancers and allows tumors to grow unrestrained and evade immune responses. Further testing and potential human clinical trials are planned.