Tag

Autophagy

All articles tagged with #autophagy

science2 days ago•8 min saved

Longevity Molecules May Fuel Cancer Growth Through a Hidden Pathway

New research from Tokyo University of Science shows polyamines—long linked to anti-aging effects via autophagy and mitochondria—can promote cancer by upregulating the translation factor eIF5A2 and boosting glycolysis, while altering ribosomal protein production. The study found polyamines lift suppression of eIF5A2 by miR-6514-5p, activating a cancer-promoting program distinct from eIF5A1’s aging-related role, suggesting context matters for polyamine supplements and identifying a potential target for cancer therapy.

via SciTechDaily|

#autophagy #cancer-metabolism #eif5a2

science14 days ago•6 min saved

Fasting Generally Doesn’t Impair Adults’ Thinking, Large Review Finds

A sweeping meta-analysis of 63 studies (3,484 participants) finds no meaningful difference in cognitive performance between fasted and fed healthy adults. Age matters (children fare worse when fasting); longer fasts may lessen performance gaps as ketones supply energy; testing later in the day and the presence of food cues can influence results; and the type of cognitive task matters. Overall, fasting appears compatible with maintained mental sharpness in adults, with caveats for kids and certain contexts, while metabolic benefits like autophagy and improved insulin sensitivity are noted but vary by individual.

via ScienceAlert|

#autophagy #cognitive-performance #fasting

health29 days ago•4 min saved

Graphic shows the body's 36-hour fasting journey: from glucose burn to autophagy

A graphic visualization explains what happens during a 36-hour fast: the body shifts from burning stored glucose to fat via ketosis, autophagy begins as nutrients run low and cellular repair accelerates after 24 hours, with peak autophagy around the 36-hour mark. The piece also notes health risks for certain individuals, stresses medical supervision, and cites studies suggesting limited eating windows may carry long-term risks.

via LADbible|

#autophagy #fasting #health

science1 month ago•4 min saved

Pesticide chlorpyrifos linked to nearly triple Parkinson's risk, UCLA study finds

A UCLA-led study links long-term chlorpyrifos exposure to about a 2.74-fold increase in Parkinson's disease risk, based on 829 PD cases and 824 controls using California pesticide-use data and residence/work addresses; animal models show dopamine neuron loss and alpha-synuclein buildup with autophagy disruption, which can be mitigated by stimulating autophagy, supporting a likely causal link while noting many factors influence PD and that chlorpyrifos use persists in the US.

via ScienceAlert|

#alpha-synuclein #autophagy #chlorpyrifos

science1 month ago•3 min saved

Chlorpyrifos Exposure Linked to Substantially Higher Parkinson’s Risk

A UCLA Health study links long-term residential exposure to the pesticide chlorpyrifos with more than a 2.5-fold increase in Parkinson’s disease risk. Animal tests show chlorpyrifos damages dopamine neurons and triggers brain inflammation via autophagy disruption, suggesting autophagy restoration as a potential therapeutic angle. Despite declines in the U.S., past exposure and ongoing use elsewhere mean monitoring and further research on pesticide-related neurodegeneration are warranted.

via SciTechDaily|

#autophagy #chlorpyrifos #neurodegeneration

health1 month ago•6 min saved

Pesticides Disrupt Brain Cell Recycling, Elevating Parkinson’s Risk

Research links the pesticide chlorpyrifos to increased Parkinson’s risk by damaging brain cell recycling systems, leading to neuron death and protein accumulation, with evidence from human data, animal models, and cellular studies highlighting the importance of environmental factors in neurodegenerative diseases.

via PsyPost|

#autophagy #brain-cell-damage #chlorpyrifos

health-and-wellness4 months ago•3 min saved

The Surprising Effects of Extended Fasting on Your Body

A simulation reveals that fasting for 36 hours triggers significant biological changes, including fat burning, autophagy, and tissue repair, but health experts advise consulting a medical professional before attempting prolonged fasts due to potential risks.

via LADbible|

#36-hours #autophagy #body-effects

health5 months ago•7 min saved

Just Days of Junk Food Can Impair Your Memory

A study on fruit flies shows that a high-fat diet can impair long-term memory within a week by disrupting the brain's cellular cleanup process, but boosting autophagy can reverse this damage, suggesting diet-related memory issues may be reversible in humans as well.

via Study Finds|

#autophagy #brain-health #health

health6 months ago•2 min saved

Natural Supplements and Green Tea May Help Prevent Alzheimer's

Researchers at UC Irvine found that a compound in green tea combined with vitamin B3 can boost brain cell energy and help clear waste linked to Alzheimer's, offering a potential dietary approach to prevent or slow the disease, though more research is needed.

via ScienceAlert|

#alzheimers #autophagy #green-tea

health1 year ago•5 min saved

Ketone Bodies Aid Brain Health by Removing Damaged Proteins

Research from the Buck Institute reveals that ketone bodies, particularly β-hydroxybutyrate, can aid in clearing damaged proteins in the brain by altering their solubility and promoting autophagy. This discovery, tested in mouse models of Alzheimer's and aging, suggests a new metabolic link to neurodegeneration and aging, offering potential therapeutic pathways. The study highlights ketone bodies as signaling metabolites that improve brain health beyond their energy-providing role during fasting.

via Neuroscience News|

#alzheimers-disease #autophagy #health

health2 years ago•3 min saved

Oral Pathogen Linked to Increased Heart Attack Damage: Scientists Uncover Hidden Peril

A study from Tokyo Medical and Dental University reveals that the oral pathogen Porphyromonas gingivalis, which causes gum disease, can hinder the self-repair of cardiac myocytes after a heart attack. The bacterium disrupts the fusion of autophagosomes and lysosomes, leading to impaired heart tissue restructuring and an increased risk of heart rupture. Treating oral infections may help prevent fatal heart attacks.

via SciTechDaily|

#autophagy #cardiac-myocytes #gum-disease

health2 years ago•2 min saved

"Spermidine: Unveiling the Truth Behind its Anti-Aging Potential"

Spermidine, a compound found in protein-making ribosomes inside cells, has gained popularity as an anti-aging supplement. It promotes autophagy, a process that disassembles damaged components and recycles them into new functioning parts. While studies in model organisms have shown positive effects on lifespan and various health markers, a recent clinical trial on older adults did not find any benefits of spermidine over a placebo. It is possible that the dose used was not high enough, but it is also likely that spermidine may not be the "anti-aging" compound researchers hoped for. Further human clinical trials are needed to determine its efficacy.

via Big Think|

#anti-aging #autophagy #clinical-trials

neuroscience2 years ago•65 min saved

Early Metabolic Changes in Alzheimer's Disease Revealed

A study using App knock-in mice, a model for Alzheimer's disease (AD), found that mitochondrial hypermetabolism occurs before the development of amyloid beta (Aβ) plaques. The study also observed impaired autophagy, declining mitochondrial function, neuroinflammation, and synaptic disturbances after the establishment of Aβ pathology. These findings suggest that mitochondrial alterations may occur in the early stages of AD and contribute to neuronal damage.

via Nature.com|

#alzheimers-disease #app-knock-in-mice #autophagy

health-and-science2 years ago•3 min saved

"The Iditarod Protein: Uniting Exercise, Cold Resistance, and Cell Repair in Fly Fitness"

Researchers have discovered a protein in fruit flies called Iditarod, which is related to human irisin and plays a crucial role in exercise benefits and cold adaptation. The gene, Iditarod, is involved in the autophagy process, which helps clean up damaged cells during intense exercise. Flies lacking the Iditarod gene had impaired exercise endurance and were unable to tolerate cold. This study highlights the evolutionary significance of this gene family in both invertebrates and mammals, emphasizing its role in muscle damage repair during exercise.

via SciTechDaily|

#autophagy #cell-repair #cold-resistance

science2 years ago•3 min saved

"Unveiling the Genetic Connection: How Exercise, Cold Tolerance, and Cellular Maintenance are Linked in Flies"

A study published in PNAS has identified a gene, called Iditarod, in fruit flies that is involved in exercise endurance, cold tolerance, and cellular maintenance. The researchers found that flies lacking the Iditarod gene had impaired exercise endurance and were unable to tolerate cold temperatures. The gene is believed to be involved in the autophagy process, which helps clean the cellular environment by removing damaged organelles or toxic byproducts. The researchers also discovered a similar gene, FNDC5, in humans, which is a precursor to the protein irisin known to be involved in exercise benefits and adaptation to cold temperatures. This study suggests that this gene family plays an important role in these physiological processes across different species.

via Phys.org|

#autophagy #cellular-maintenance #cold-tolerance