Early Metabolic Changes in Alzheimer's Disease Revealed

A study using App knock-in mice, a model for Alzheimer's disease (AD), found that mitochondrial hypermetabolism occurs before the development of amyloid beta (Aβ) plaques. The study also observed impaired autophagy, declining mitochondrial function, neuroinflammation, and synaptic disturbances after the establishment of Aβ pathology. These findings suggest that mitochondrial alterations may occur in the early stages of AD and contribute to neuronal damage.