All articles tagged with #cancer metabolism
The study demonstrates that combining a diet free of proline and arginine with the polyamine synthesis inhibitor DFMO significantly suppresses neuroblastoma growth in mouse models by depleting polyamines, inducing tumor differentiation, and disrupting translation at specific codons, offering a promising therapeutic strategy for this childhood cancer.
The study reveals that cancer cells can produce cytosolic acetyl-CoA from β-hydroxybutyrate (β-OHB) via two pathways: the mitochondrial citrate-dependent route involving OXCT1 and a citrate-independent route involving AACS, supporting tumor growth especially under nutrient-limited conditions.
Scientists discovered that glioblastoma brain tumors in mice grow more slowly when deprived of the amino acid serine, revealing a potential metabolic vulnerability that could be targeted for therapy. The tumors typically steal nutrients like serine from their environment to support rapid growth, but a serine-deficient diet slowed tumor progression and extended survival in mice, offering new hope for treatment strategies.
Scientists from Osaka Metropolitan University discovered that a compound in ginger called EMC can inhibit cancer growth by disrupting fatty acid synthesis, revealing a new potential target for cancer therapy and expanding understanding of cancer metabolism beyond the traditional Warburg effect.