NAC Regulates Nascent Chain Fate via Tunnel Sensing and Chaperone Activity
Originally Published 21 days ago — by Nature
The study reveals that the nascent polypeptide-associated complex (NAC) plays a multifaceted role in protein synthesis by coordinating translation, folding, and targeting through sequence-specific interactions both inside and outside the ribosome tunnel, including an intra-tunnel sensing mechanism that influences translation kinetics and proteostasis.