All articles tagged with #piezo1
Scientists from HKUMed discovered that the Piezo1 protein acts as an 'exercise sensor' in bones, translating physical activity into signals that strengthen bones and reduce fat accumulation in bone marrow. This breakthrough could lead to the development of drugs that mimic exercise effects, offering new treatments for osteoporosis, especially for those unable to exercise.
Scientists at the University of Vermont have discovered that increasing levels of the phospholipid PIP2 in brain cell membranes may help regulate blood flow in the brain by inhibiting the Piezo1 protein, potentially offering a new approach to treat dementia and related neurovascular diseases.
Scientists at the University of Vermont have discovered that restoring levels of the phospholipid PIP2 can reduce overactivity of the Piezo1 protein in brain blood vessels, potentially improving blood flow and alleviating symptoms of dementia, offering a promising new avenue for treatment.
A new study suggests that interbreeding between Neanderthals and Homo sapiens introduced a gene variant in Neanderthals that may have caused reproductive issues, potentially contributing to their eventual extinction by creating a genetic mismatch that reduced their survival over generations.
Researchers at Imperial College London have successfully filmed the activity of Piezo1 and Piezo2, bodily "pressure sensors" that won the 2021 Nobel Prize in Physiology or Medicine. These ion channels are found throughout the body and play a crucial role in regulating blood pressure, respiration, bladder control, and the immune system. By developing a specific biosensor called GenEPi, the researchers were able to visualize the activity of Piezo1 channels in various cells and organisms. This non-invasive method could lead to new drug targets for diseases such as cancer and provide insights into fundamental physiological processes.