Lipid brake on brain blood flow opens new path for dementia therapy

Researchers found that PIP2 acts as a brake on Piezo1, a pressure sensor in brain vessels. In Alzheimer’s-model mice, low PIP2 led to Piezo1 overactivation and disrupted brain blood flow, but restoring PIP2 largely normalized flow, suggesting a potential new therapeutic target for dementia—though findings are early and based on mouse studies.