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Parkinsons Disease

All articles tagged with #parkinsons disease

VA Research Highlights: Agent Orange linked to acral melanoma, gut bacteria tied to Parkinson's, and a heart drug may curb opioid withdrawal
health5 days ago

VA Research Highlights: Agent Orange linked to acral melanoma, gut bacteria tied to Parkinson's, and a heart drug may curb opioid withdrawal

VA researchers publish three News Briefs: exposure to Agent Orange is linked to a higher risk of acral melanoma (a rare form of skin cancer); a gut bacterium, Desulfovibrio vulgaris, may drive Parkinson's disease by promoting alpha-synuclein buildup and affecting dopamine signaling; and acetazolamide, a heart disease drug, reversed opioid withdrawal–related brain changes in a mouse model, suggesting potential non-opioid treatments for substance-use disorders.

via VA News (.gov)|
#acral-melanoma#agent-orange#gut-microbiome
Movement-drug cravings: hundreds report addictions linked to common Parkinson’s/Restless Legs meds
health5 days ago

Movement-drug cravings: hundreds report addictions linked to common Parkinson’s/Restless Legs meds

BBC reporting shows hundreds of patients on dopamine-agonist medications for movement disorders report impulse-control problems such as gambling, sex, and shopping addictions, leading to debt, relationship breakdowns, and even legal issues. Many patients say doctors failed to warn about these side effects, and despite changes in guidance, prescribing remains high. Regulators and courts are examining warnings and liability, with ongoing cases in Europe and calls for clearer patient information.

via BBC|
#dopamine-agonist#gambling-addiction#health
Hair Clues Point to Metal Imbalances in Parkinson's
science5 days ago

Hair Clues Point to Metal Imbalances in Parkinson's

In a small study of 60 Parkinson's patients and matched controls, researchers found distinctive metal profiles in hair—lower iron and copper with higher manganese and arsenic—raising the possibility of a non-invasive diagnostic biomarker. Mouse data linked hair iron deficiency to gut dysfunction, highlighting a gut–brain connection; further, larger studies are needed to confirm causality and mechanism and to validate hair metal patterns as a PD diagnostic tool.

via ScienceAlert|
#biomarkers#gut-microbiome#hair-biomarker
Jesse Jackson, trailblazing civil rights leader, dies at 84
us-news9 days ago

Jesse Jackson, trailblazing civil rights leader, dies at 84

Jesse Jackson, the famed civil rights leader who marched with Martin Luther King Jr. and later ran for president, died at 84 after battling progressive supranuclear palsy following a Parkinson's diagnosis; he leaves behind his wife and five children, with public observances planned in Chicago, and his legacy includes founding PUSH and The Rainbow Coalition and inspiring a generation of activists.

via CBS News|
#civil-rights#jesse-jackson#parkinsons-disease
Late-Life Depression Linked to Early Parkinson's or Lewy Body Dementia, Study Finds
health9 days ago

Late-Life Depression Linked to Early Parkinson's or Lewy Body Dementia, Study Finds

A Danish study following 17,711 people over 12 years found that depression is more common years before a diagnosis of Parkinson's disease or Lewy body dementia, with rates rising about eight years prior and remaining elevated after diagnosis, strongest for Lewy body dementia. By comparing with rheumatoid arthritis, chronic kidney disease, and osteoporosis, researchers suggest the link isn’t solely due to disability. The study shows association, not causation, and supports screening older adults with new or late-onset depression for early neurodegenerative signs to enable earlier care and research.

via ScienceAlert|
#depression#early-detection#health
Engineered Stem Cells Target Dopamine Rebuilding in Parkinson's Trial
health11 days ago

Engineered Stem Cells Target Dopamine Rebuilding in Parkinson's Trial

Keck Medicine of USC leads an early-stage trial testing induced pluripotent stem cells engineered to become dopamine-producing brain cells, implanted into the basal ganglia to restore dopamine and motor function in Parkinson’s disease; the 12-participant, multi-site study monitors safety and efficacy for 12–15 months after surgery, with up to five years of follow-up.

via SciTechDaily|
#clinical-trial#dopamine#health
Rhythmic CO2 Pulses May Boost Brain Waste Clearance in Parkinson's
science25 days ago

Rhythmic CO2 Pulses May Boost Brain Waste Clearance in Parkinson's

Researchers find that brief, rhythmic increases in CO2 (intermittent hypercapnia) can enhance glymphatic clearance and cerebrospinal fluid flow in both healthy individuals and people with Parkinson's, potentially aiding removal of brain toxins such as amyloid-beta; however, the durability of the effect and its impact on disease progression remain unclear.

via ScienceAlert|
#amyloid-beta#cerebrospinal-fluid#glymphatic-system
Blood biomarkers hint at decades-early warning for Parkinson’s
health26 days ago

Blood biomarkers hint at decades-early warning for Parkinson’s

A European study found that blood biomarkers linked to early DNA repair and cellular stress, identified with machine learning, may reveal Parkinson’s long before motor symptoms, paving the way for inexpensive blood tests and earlier treatment—with clinical usage potentially within five years—though brain changes may not fully match blood signals and no cure exists.

via Fox News|
#biomarkers#blood-test#early-detection
Four early non-motor clues that may precede Parkinson’s by years
health29 days ago

Four early non-motor clues that may precede Parkinson’s by years

Non-motor signs can appear years before Parkinson’s motor symptoms. Loss of smell may begin up to about 20 years before diagnosis; REM sleep behavior disorder markedly increases future risk (many develop Parkinson’s within 5–10 years); constipation and orthostatic hypotension are also early markers with varying strength. These signs aren’t diagnostic alone, but multiple markers or a family history warrant medical evaluation, and smell tests are available through research programs.

via The Washington Post|
#anosmia#health#non-motor-symptoms
Michael J. Fox Reunites with Harrison Ford in Shrinking Season 3 Clip, Drops 'Fuck Parkinson’s'
tv-and-movies29 days ago

Michael J. Fox Reunites with Harrison Ford in Shrinking Season 3 Clip, Drops 'Fuck Parkinson’s'

Michael J. Fox returns to screen in a Shrinking Season 3 clip featuring Harrison Ford; the scene from the opening episode “My Bad” shows Ford’s therapist waiting room moment with Fox’s Gerry and includes a defiant line about Parkinson’s. The clip serves as a Rolling Stone exclusive ahead of Shrinking’s Jan. 28 Apple TV premiere, and the season also features guests like Daniels, Sherry Cola, Candice Bergen, and Isabella Gomez alongside the main cast.

via Rolling Stone|
#apple-tv#harrison-ford#michael-j-fox
Decoy Therapy Reverses Mitochondrial Failure in Parkinson's Models
science1 month ago

Decoy Therapy Reverses Mitochondrial Failure in Parkinson's Models

Scientists show that alpha-synuclein directly binds the ClpP enzyme, sabotaging mitochondria and fueling neuron loss in Parkinson's models; they created CS2, a decoy that blocks this interaction, restoring mitochondrial function, reducing inflammation, and improving movement and cognition in tissue and animal models, with plans to advance toward human trials.

via SciTechDaily|
#alpha-synuclein#clpp#cs2