Decoy Therapy Reverses Mitochondrial Failure in Parkinson's Models
TL;DR Summary
Scientists show that alpha-synuclein directly binds the ClpP enzyme, sabotaging mitochondria and fueling neuron loss in Parkinson's models; they created CS2, a decoy that blocks this interaction, restoring mitochondrial function, reducing inflammation, and improving movement and cognition in tissue and animal models, with plans to advance toward human trials.
- Researchers Restore Brain Cell Function in Parkinson’s Models SciTechDaily
- Researchers discover potential new target to treat Parkinson’s disease Case Western Reserve University
- Lewy body formation in Parkinson's disease: Scientists propose a new molecular roadmap Medical Xpress
- Scientists identify hidden protein interaction driving Parkinson’s disease ScienceDaily
- Recent breakthroughs in Parkinson’s disease laying the groundwork for new treatments thestar.com
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