
2026 Acute PE Guideline Introduces Five-Category Risk System to Guide Management
The 2026 AHA/ACC guideline for acute PE introduces a five-category Acute PE Clinical Categories system (A–E) to sharpen risk stratification and guide therapy; patients with higher risk (categories C–E) or cardiopulmonary failure should be hospitalized, and for those eligible for oral anticoagulation, direct oral anticoagulants are preferred over vitamin K antagonists to prevent recurrent VTE and reduce major bleeding.













