All articles tagged with #niacin
Researchers have discovered that vitamin B3 (niacin) can effectively target a genetic factor, miR-93, involved in fatty liver disease (MASLD), by reducing lipid accumulation and improving liver function, suggesting a promising, safe, and affordable treatment option through drug repurposing.
A recent study has linked a niacin derivative to an increased risk for cardiovascular events, prompting questions about the safety of niacin intake. The findings suggest that excessive niacin intake may be harmful, leading to potential adverse effects on cardiovascular risk. While some experts advise avoiding niacin supplements and high-protein diets, others caution that a causal link has not been proven and further research is needed. The study's implications also raise questions about niacin fortification in food and its use in skin cancer prevention, with differing opinions on the effects of nicotinamide supplementation.
A study published in Nature Medicine suggests that high blood levels of niacin breakdown products are linked to an elevated risk of major adverse cardiovascular events (MACE), independent of known risk factors such as high cholesterol. The study, led by Stanley Hazen, chair of Cardiovascular and Metabolic Sciences at Cleveland Clinic's Lerner Research Institute, found that excess niacin intake from fortified foods may be exacerbating cardiovascular disease, increasing risks of heart attacks, strokes, and death. This unexpected link could open up new avenues for treatment and prevention of cardiovascular disease.
A new study from researchers at Cleveland Clinic warns that excessive levels of vitamin B3, also known as niacin, can increase the risk of cardiovascular disease. Vitamin B3 is added to processed foods to prevent deficiency, but the study found that too much of it can lead to the formation of a blood metabolite called 4PY, triggering inflammation and damaging blood vessels. The study suggests a need for caution with niacin supplements and a focus on a diet rich in fruits and vegetables while avoiding excess carbohydrates.
A new study published in Nature Medicine suggests that high levels of niacin, a B vitamin found in many foods and added to fortified cereals and breads, may actually raise the risk of heart disease by triggering inflammation and damaging blood vessels. The study found that a substance made when there is too much niacin in the body, called 4PY, was strongly linked with patients who have had a heart attack, stroke, or other cardiac event. Experts caution against routine intake of niacin supplements and recommend consulting with a healthcare provider before taking high doses of niacin for cholesterol management.
A recent study published in Nature Medicine suggests that high levels of niacin, also known as vitamin B3, may increase the risk of heart disease by triggering inflammation and damaging blood vessels. While niacin is essential for energy metabolism and skin health, the study raises concerns about its impact on heart health, particularly in high doses. Experts caution against routine intake of niacin supplements and recommend consulting with a healthcare provider, especially for those currently taking large doses of niacin for cholesterol management. The study prompts a reevaluation of the fortification of flour and cereal with niacin in the U.S., and emphasizes the importance of obtaining vitamins from food sources and maintaining a balanced diet.
Excess niacin metabolism was found to be associated with major adverse cardiovascular events (MACE), with two breakdown products, 2PY and 4PY, showing a strong link to myocardial infarction, stroke, and other adverse cardiac events. The study suggests that niacin supplementation may require a more nuanced, titrated approach to avoid excess 4PY generation, which is associated with increased MACE risk. The findings highlight the potential impact of niacin levels on cardiovascular health and the need for careful consideration of niacin supplementation.
A study led by researchers from the Cleveland Clinic suggests that taking niacin, also known as Vitamin B3, in excess through supplements could increase the risk of heart disease. The study found that the byproduct created when the body breaks down niacin triggers inflammation in the circulatory system, leading to potential damage to blood vessels and an increased risk of atherosclerosis, stroke, heart attack, or other major heart problems. The findings shed light on the previously puzzling "niacin paradox" and raise questions about the continued fortification of flour and cereals with niacin in the U.S.
Researchers at the Cleveland Clinic have discovered a new pathway linking high levels of niacin (vitamin B-3) to cardiovascular disease. They found that a byproduct of excess niacin, called 4PY, is associated with an increased risk of heart attack, stroke, and vascular inflammation. The study suggests potential new interventions and therapeutics to counteract this pathway and raises questions about the continued fortification of staple foods with niacin. The findings may also help explain why niacin is no longer a primary treatment for lowering cholesterol and emphasize the importance of investigating residual cardiovascular risk.
Excess levels of niacin, also known as vitamin B3, have been linked to a higher risk of heart disease, heart attack, stroke, and other adverse cardiac events. Research suggests that high levels of 4PY, a breakdown product of excess niacin, can trigger vascular inflammation, leading to atherosclerosis. While niacin deficiency is rare in the U.S. due to fortification in staple foods, some individuals take it as a dietary supplement or prescription. However, the study suggests that supplementation may not be necessary and that individuals should focus on maintaining healthy niacin levels through a balanced diet.
A new study from the Cleveland Clinic has found a strong link between excessive niacin intake and increased risk for cardiovascular disease, identifying a breakdown product from excess niacin, 4PY, as a significant contributor to the development of heart disease. While niacin fortification in staple foods has been mandated in many countries to prevent nutritional deficiency, the study suggests that too much niacin can lead to inflammation of blood vessels, strongly linked to heart disease. The findings raise questions about the continued mandate of niacin fortification in the U.S. and suggest that dietary supplements containing niacin should be consumed with caution and preferably substituted with a diet rich in fruits and vegetables.
New research suggests that high levels of niacin, an essential B vitamin found in foods like meat, fish, nuts, and fortified cereals and breads, may increase the risk of heart disease by triggering inflammation and damaging blood vessels. The study, published in Nature Medicine, found that excessive niacin levels are linked to a substance in the blood that predicts the risk of heart attack, stroke, and death. The discovery could lead to the development of medications to reduce blood vessel inflammation and influence dietary recommendations for niacin intake.
A study suggests that niacin, a common B vitamin added to fortified foods like breakfast cereals, pasta, and bread, may be linked to heart disease. Researchers found that a byproduct of niacin called 4PY is strongly associated with heart attacks, strokes, and cardiac conditions. While niacin deficiency can lead to serious health issues, excessive intake may pose risks. The study raises questions about the continued fortification of foods with niacin and highlights the importance of investigating residual cardiovascular risk. The NHS recommends a balanced diet that includes a variety of food groups and specific daily allowances for nutrients.
Researchers at the Cleveland Clinic have discovered a link between high levels of niacin, a common B vitamin, and cardiovascular disease. They found that a breakdown product from excess niacin, called 4PY, is strongly associated with the development of heart attack, stroke, and other adverse cardiac events. This discovery may lead to potential new interventions and therapeutics to reduce or prevent vascular inflammation. The study also suggests that over-the-counter niacin supplements and fortified foods may contribute to elevated 4PY levels, and emphasizes the importance of consulting with healthcare professionals before taking such supplements.
Niacin, a popular supplement, can cause dangerous side effects such as flushed skin, digestive issues, liver damage, and high blood sugar if taken in large doses. Nutritionist Lisa Richards warns that high doses of niacin can cause flushing of the skin, stomach upset, nausea, vomiting, and diarrhea. Extremely high doses of niacin may cause liver toxicity, and niacin can elevate blood sugar levels, particularly in individuals with diabetes. It's important to speak to a doctor before adding niacin to your regimen and to follow the guidelines to ensure you're taking safe doses.