All articles tagged with #neutrophils
Early data from Neutrolis suggests that a DNA-chopping enzyme that breaks up neutrophil extracellular traps (NETs) could offer a new approach to treating autoimmune diseases by targeting a unique immune mechanism.
A study shows that chronic stress causes immune cells called neutrophils to leave skull bone marrow and gather in the brain's membranes, contributing to depression symptoms. Blocking an immune pathway reduced these cells and improved mood in mice, suggesting new immune-targeted treatments for depression, especially for those unresponsive to current drugs.
Scientists have discovered that mitochondria, traditionally known for energy production, also play a crucial role in immune defense by sensing bacterial lactate and triggering neutrophil extracellular traps (NETs) to trap and kill bacteria. Dysfunctional mitochondria may weaken immune responses, as seen in autoimmune diseases like lupus, highlighting their importance in balancing immune activity and infection defense.
Recent research reveals that mitochondria in neutrophils can detect bacterial lactate, triggering the formation of NETs to trap and kill bacteria, a process that is impaired in autoimmune diseases like lupus, highlighting mitochondria's crucial role in immune defense and potential therapeutic targets.
A study published in Science Immunology reveals that exposure to daylight enhances the immune response by regulating the circadian clock in neutrophils, the body's first responders to infection, with potential implications for treating inflammatory conditions.
Researchers at the University of Auckland discovered that daylight activates circadian clocks in neutrophils, enhancing their ability to fight bacteria during the day, which could lead to new therapies targeting these cellular clocks to improve immune responses.
A study by researchers at Cold Spring Harbor Laboratory has revealed that chronic stress can increase the spread of cancer by causing certain white blood cells called neutrophils to form sticky web-like structures, making body tissues more susceptible to metastasis. The team's experiments on mice showed a significant increase in metastatic lesions in stressed animals, which was attributed to stress hormones acting on neutrophils to form these structures. The findings suggest that reducing stress and developing drugs to prevent the formation of these structures could be important components of cancer treatment and prevention.
Chronic stress can lead to a significant increase in cancer metastasis by activating neutrophils to form web-like structures that promote cancer spread. This breakthrough suggests that targeting neutrophil extracellular traps (NETs) formation could be a viable strategy to prevent cancer metastasis, emphasizing the importance of stress management as an essential part of cancer treatment and prevention. The findings offer potential new treatment strategies and highlight the need for integrating stress reduction in cancer care.
A breakthrough blood test is being trialled that can rapidly detect sepsis, a condition that is difficult to diagnose. Sepsis kills more people annually in the UK than breast, prostate, and bowel cancer combined. The test can produce results in less than 45 minutes and costs between £20 and £30. It relies on neutrophils, the body's first line of defense against infection, which become activated during an infection and produce a specific protein that can be detected in the blood.
New research suggests that ginger supplements may have a promising role in managing inflammation in individuals with autoimmune diseases. The study found that ginger can influence neutrophils, making them less susceptible to a process called NETosis, which is linked to inflammation and various autoimmune conditions. Ginger supplements could potentially revolutionize the management of autoimmune diseases by changing how specific immune cells function. Further research is needed to explore the therapeutic potential of ginger supplements in treating autoimmune and inflammatory conditions.
Researchers at Kyoto University have found that neutrophils, a type of white blood cell, can induce anti-inflammatory macrophages (M2) within granulomas, which are dense globular structures that form during chronic inflammation. This M2 macrophage polarization can help regulate inflammation and tissue health. The team believes that their findings, derived from studying tuberculosis, could also be applied to tumor development. This finding could contribute to more effective cancer drug development.