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Metformin

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Metformin May Extend Longevity for Older Women, Study Finds
science10 days ago

Metformin May Extend Longevity for Older Women, Study Finds

A study of 438 postmenopausal women with type 2 diabetes suggests that starting metformin is associated with about a 30% lower risk of dying before age 90 compared with sulfonylurea therapy, hinting at metformin's potential aging‑related benefits. However, the findings are observational (not randomized), with no placebo group and a modest sample size; the long follow‑up of 14–15 years strengthens the signal but cannot prove causality, and randomized trials are needed to confirm longevity effects.

via ScienceAlert|
#aging#diabetes#geroscience
Diabetes Drug Metformin Linked to Slower Age-Related Vision Loss
health22 days ago

Diabetes Drug Metformin Linked to Slower Age-Related Vision Loss

A Liverpool study of about 2,000 adults with diabetes aged 50+ found that those taking metformin had 37% lower odds of developing intermediate age-related macular degeneration (AMD) over five years compared with non-users, suggesting metformin might help slow age-related vision loss. However, researchers caution that the findings are observational and do not prove causation or support using metformin to treat AMD outside of diabetes; clinical trials are needed to confirm any benefit.

via Healthline|
#age-related-macular-degeneration#diabetes#eye-health
Metformin May Cut Long-COVID Risk When Used During COVID, Review Finds
health24 days ago

Metformin May Cut Long-COVID Risk When Used During COVID, Review Finds

A literature review of randomized trials and health-record analyses suggests that taking metformin during acute COVID-19 can reduce the risk of developing long COVID by roughly 40%–60%, though it is studied for prevention rather than treatment of existing long COVID; findings, including the COVID-OUT trial and EHR-based studies, have replicated this protective effect and point to possible antiviral benefits and compatibility with other antivirals, making metformin a potential low-cost outpatient preventive option.

via CIDRAP|
#covid-19#electronic-health-records#health
Scientists Discover Unexpected Brain Effects of Common Diabetes Medication
health3 months ago

Scientists Discover Unexpected Brain Effects of Common Diabetes Medication

Scientists have discovered that metformin, a widely used diabetes drug, works through a brain pathway involving the ventromedial hypothalamus and a protein called Rap1, revealing new insights into its mechanism and potential effects on appetite, weight, and cognition. More research is needed, but these findings could lead to improved treatments for diabetes and other neurological conditions.

via Prevention|
#blood-sugar#brain-pathway#diabetes
Scientists Discover Unexpected Brain Effects of Common Diabetes Medication
health3 months ago

Scientists Discover Unexpected Brain Effects of Common Diabetes Medication

Scientists have discovered that the diabetes drug metformin impacts the brain, particularly through a pathway involving the ventromedial hypothalamus and a protein called Rap1, which may explain some of its effects on weight, appetite, and cognition. This new understanding could lead to broader applications of the drug beyond blood sugar control, although further research is needed, especially in humans.

via Yahoo|
#brain#diabetes#glucose-regulation
Metformin Use May Reduce Benefits of Daily Walks
health3 months ago

Metformin Use May Reduce Benefits of Daily Walks

A Rutgers-led study found that metformin may reduce the benefits of exercise on blood vessel function, fitness, and blood sugar control, raising concerns about its combined use for diabetes prevention and treatment. The research suggests that metformin could interfere with cellular adaptations to exercise, potentially impacting long-term health outcomes for at-risk individuals.

via Medical Xpress|
#blood-sugar#diabetes-prevention#exercise
Metformin's Hidden Brain Pathway Discovered After Six Decades
science5 months ago

Metformin's Hidden Brain Pathway Discovered After Six Decades

Researchers have discovered that metformin, a common diabetes drug, also acts in the brain, specifically in the ventromedial hypothalamus, by turning off the protein Rap1, which is essential for its blood sugar-lowering effects. This finding suggests new avenues for more targeted diabetes treatments and highlights the brain's role in metformin's mechanism of action.

via ScienceDaily|
#brain-pathway#diabetes#hypothalamus
Metformin's Hidden Impact on Body Metals Uncovered
health6 months ago

Metformin's Hidden Impact on Body Metals Uncovered

Researchers at Kobe University have discovered that metformin, a common diabetes medication, alters blood levels of copper, iron, and zinc, which may explain its broad protective effects beyond blood sugar control. The study found that metformin lowers copper and iron while increasing zinc levels in patients, potentially contributing to improved glucose tolerance and reduced complications. This insight could lead to the development of more targeted diabetes treatments.

via SciTechDaily|
#copper#diabetes#health