Tag

Geroscience

All articles tagged with #geroscience

Metformin May Extend Longevity for Older Women, Study Finds
science10 days ago

Metformin May Extend Longevity for Older Women, Study Finds

A study of 438 postmenopausal women with type 2 diabetes suggests that starting metformin is associated with about a 30% lower risk of dying before age 90 compared with sulfonylurea therapy, hinting at metformin's potential aging‑related benefits. However, the findings are observational (not randomized), with no placebo group and a modest sample size; the long follow‑up of 14–15 years strengthens the signal but cannot prove causality, and randomized trials are needed to confirm longevity effects.

Blood Pressure Drug Extends Lifespan and Slows Aging in Older Animals
health8 months ago

Blood Pressure Drug Extends Lifespan and Slows Aging in Older Animals

A common blood pressure medication, rilmenidine, has been shown to extend lifespan in worms and mice by activating cellular pathways associated with caloric restriction, suggesting potential for anti-aging therapies in humans. The drug works by binding to imidazoline receptors, promoting autophagy and stress resistance, and could offer a practical alternative to calorie restriction for healthy aging.

"Slowing the Pace of Aging: Is It Possible?"
health-and-science1 year ago

"Slowing the Pace of Aging: Is It Possible?"

A new tool called DunedinPACE can assess the pace of aging at a cellular level, revealing that a low-calorie diet, longer education, metal exposure, childhood hardships, and the Mediterranean diet all impact aging. The tool has shown that reducing caloric intake by 25% can slow aging by 2-3%, while staying in school longer correlates with slower aging and longer lifespan. Metal exposure accelerates aging, and children facing hardships age faster. Additionally, the Mediterranean diet slows aging and reduces the risk of developing Alzheimer's disease.

Unlocking the Secrets to a Longer, Healthier Life
health2 years ago

Unlocking the Secrets to a Longer, Healthier Life

Geroscientists are studying how to maintain or enhance the function of physical systems that fade over time to prevent age-related diseases. Israeli researchers presented their latest findings on the biology of aging at the Longevity Nation conference, including personalized cell therapy to restore mitochondrial function, increasing VEGF signaling capacity to delay vascular aging, eliminating senescent cells to extend lifespan, and activating SIRT6 enzyme to block frailty. The role of genetics and environment in exceptional longevity was also discussed, with the "switch theory" suggesting that ELIs have many more "dimmer switches" to adapt to any given environment.