Scientists at Mount Sinai have discovered that reactivating the Cyclin A2 (CCNA2) gene in adult hearts can promote self-healing after injuries like heart attacks, potentially revolutionizing treatment by enabling natural heart regeneration and reducing reliance on transplants or mechanical devices.
Scientists at Mount Sinai have discovered a method to stimulate adult human heart cells to divide and regenerate by reactivating the dormant gene CCNA2, potentially leading to new treatments for heart damage and reducing the need for transplants.
Researchers have discovered a mechanism involving LRRC10 in zebrafish that promotes the maturation of heart muscle cells during the regeneration process. This finding, applicable to human cells, could lead to new treatments for cardiovascular diseases by replacing lost heart tissue. The study shows that examining the natural heart regeneration process in zebrafish and applying these discoveries to human heart muscle cells may contribute to the development of therapies against cardiovascular diseases, which are a leading cause of death worldwide.
Scientists at the University of Washington School of Medicine have used CRISPR-based genome editing to create stem cells that do not cause dangerous arrhythmias, a major complication previously hindering stem-cell therapies for injured hearts. The team created a new line of cells called “MEDUSA,” which engraft in the heart, mature, and integrate into heart muscle without generating dangerous heart rates. This breakthrough could pave the way for safe and effective stem cell therapy for heart regeneration.