Mitochondrial 'Spider' Triggers Cell-Wide Stress Response
Scientists at Scripps Research have discovered a mitochondrial protein structure, composed of the DELE1 protein, that is crucial for activating the cell's integrated stress response (ISR). This finding could have implications for the development of therapeutics for age-related diseases, such as neurodegeneration. The researchers identified that the DELE1 protein forms an octamer, or an oligomeric structure, which is necessary for initiating the ISR. Understanding and manipulating this pathway could lead to potential treatments for various disorders.