All articles tagged with #cell stress response
Scientists have identified a cellular 'switch' involving mitochondrial stress response that could potentially reverse type 2 diabetes by restoring normal insulin production, offering a promising new avenue for treatment beyond managing symptoms.
Scientists at Scripps Research have discovered a mitochondrial protein structure, composed of the DELE1 protein, that is crucial for activating the cell's integrated stress response (ISR). This finding could have implications for the development of therapeutics for age-related diseases, such as neurodegeneration. The researchers identified that the DELE1 protein forms an octamer, or an oligomeric structure, which is necessary for initiating the ISR. Understanding and manipulating this pathway could lead to potential treatments for various disorders.