health-genetics2.795 min read
"Genetic Links Between Diabetes and Cancers Uncovered in Breakthrough Study"
1 year ago•Source: The Telegraph
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4.065 min•1 year ago
"Genetic Influence on Cancer Risk from Red and Processed Meats"
A study published in Cancer Epidemiology, Biomarkers & Prevention suggests that genetics may influence the risk of colorectal cancer from consuming red and processed meats. Researchers identified two genetic markers that may increase the risk for some individuals. The study analyzed data from nearly 30,000 people with colorectal cancer and found that certain genetic variants could elevate the risk of cancer when consuming high levels of red and processed meats. The findings provide insight into potential mechanisms behind the development of colorectal cancer and may lead to further experimental studies.
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Uncovering Genetic Markers Driving Type 2 Diabetes Heterogeneity
Nature.com•1 year ago
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Unraveling the Genetic Links to Prostate Cancer Risk in Black Men
The Guardian•1 year ago
More Health Genetics Stories
"Uncovering the Stealthy Threat: Preventing Deadly Heart Attacks and Strokes Linked to Cholesterol"
Originally Published 1 year ago — by NBC News
Millions of Americans are genetically predisposed to high levels of a dangerous cholesterol called lipoprotein(a) (Lp(a), which can lead to deadly heart attacks and strokes by middle age. Routine blood cholesterol tests do not screen for Lp(a) due to lack of effective treatment, but several promising drugs are in clinical trials. Doctors are calling for wider testing and proactive prevention measures, such as maintaining a healthy lifestyle, for those at risk. Despite the lack of available drugs, knowing one's Lp(a) levels can be life-saving, as it can lead to more intentional diet and exercise, potentially reducing heart risks.
"Early Life Origins of Schizophrenia: Uncovering the Seed"
Originally Published 1 year ago — by ScienceAlert
Researchers have identified two genetic deletions, NRXN1 and ABCB11, associated with schizophrenia that likely occur during early gestation, suggesting that the seeds of schizophrenia may not always be inherited but acquired before birth. These findings open the door to early prevention and shed light on the complex mix of genetic and environmental factors contributing to the disorder. More research is needed to understand the extent of their contribution to the genetic architecture of schizophrenia.
"Unraveling the Genetic Origins of Multiple Sclerosis through Ancient DNA"
Originally Published 2 years ago — by NBC News
Ancient DNA analysis suggests that the higher risk of multiple sclerosis among people of northern European ancestry may be linked to genetic variants introduced by Bronze Age horseback-riding cattle herders who migrated into the region 5,000 years ago. These gene variants, which are known to increase the risk of multiple sclerosis, likely provided an advantage to the herders by protecting them from infections carried by their livestock. The findings shed light on the north-south divide in multiple sclerosis rates in Europe and may help explain the genetic basis of the disease.
"Unraveling the Ancient Origins of Multiple Sclerosis in Northern Europe"
Originally Published 2 years ago — by The Guardian
Ancient DNA analysis reveals that the higher risk of multiple sclerosis among northern Europeans is linked to gene variants brought by the Yamnaya, a bronze age people who migrated into the region 5,000 years ago. These gene variants, which likely provided an advantage to the nomadic herders against infections carried by their livestock, are now associated with an increased risk of multiple sclerosis. The findings shed light on the genetic legacy of ancient migrations and offer a potential explanation for the north-south divide in multiple sclerosis prevalence in Europe.
Uncovering the Ancient Origins of Multiple Sclerosis in European Descendants
Originally Published 2 years ago — by The Washington Post
A new study of DNA from ancient and present-day people suggests that the genetic risk for multiple sclerosis in people of northern European descent may have originated from the migration of sheep and cattle herders from Asia to Europe 5,000 years ago. The research indicates that gene variants related to immunity, which provided an evolutionary advantage against infectious perils in the past, also increase the risk of the autoimmune disease. Analysis of ancient DNA from over 300 individuals has revealed insights into the roots and spread of disease risk, shedding light on the impact of migration events on disease susceptibility and human traits. While this understanding may not directly lead to new treatments, it offers a valuable perspective for advancing drug development.
"Uncovering the Ancient Origins of Multiple Sclerosis Risk in Modern Populations"
Originally Published 2 years ago — by Nature.com
A study has found that steppe pastoralist populations have an elevated genetic risk for multiple sclerosis (MS), an autoimmune disease affecting the brain and spinal cord. The research suggests that genetic factors, particularly those associated with steppe ancestry, contribute significantly to the risk of developing MS. The study also indicates that MS risk variants, particularly the HLA-DRB1*15:01 allele, underwent positive selection around 5,000 to 2,000 years ago in steppe populations. This research provides insights into the genetic and evolutionary factors influencing the prevalence of MS in different populations.