Uncovering the Ancient Origins of Multiple Sclerosis in European Descendants

A new study of DNA from ancient and present-day people suggests that the genetic risk for multiple sclerosis in people of northern European descent may have originated from the migration of sheep and cattle herders from Asia to Europe 5,000 years ago. The research indicates that gene variants related to immunity, which provided an evolutionary advantage against infectious perils in the past, also increase the risk of the autoimmune disease. Analysis of ancient DNA from over 300 individuals has revealed insights into the roots and spread of disease risk, shedding light on the impact of migration events on disease susceptibility and human traits. While this understanding may not directly lead to new treatments, it offers a valuable perspective for advancing drug development.