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Single Molecule Imaging

All articles tagged with #single molecule imaging

BonFIRE Unveils Stunning Molecular Diversity in Life through Microscopy

Originally Published 2 years ago — by SciTechDaily

Featured image for BonFIRE Unveils Stunning Molecular Diversity in Life through Microscopy
Source: SciTechDaily

Scientists at the California Institute of Technology (Caltech) have developed a new microscopy technique called BonFIRE, which combines fluorescence microscopy and vibrational microscopy. This innovative method allows for greater selectivity and sensitivity, enabling researchers to visualize biological processes at the single-molecule level. By coupling vibrations to fluorescence, BonFIRE combines the strengths of both techniques, providing rich chemical information and the ability to image entire cells or single molecules. The researchers also demonstrate the ability to tag biomolecules with different colors, revealing the molecular diversity of life in stunning detail.

Illuminating Human mRNA Decoding Mechanism.

Originally Published 2 years ago — by Nature.com

Featured image for Illuminating Human mRNA Decoding Mechanism.
Source: Nature.com

Researchers have used single-molecule imaging and cryo-electron microscopy techniques to investigate the mechanism of messenger-RNA decoding in humans and found that human ribosomes function differently than those of bacteria, explaining why they are slower and more accurate. Ribosomes use messenger-RNA sequences to synthesize proteins, and these findings shed light on the structural and kinetic differences in this process between cell-nucleus-bearing species and bacteria.