BonFIRE Unveils Stunning Molecular Diversity in Life through Microscopy

Scientists at the California Institute of Technology (Caltech) have developed a new microscopy technique called BonFIRE, which combines fluorescence microscopy and vibrational microscopy. This innovative method allows for greater selectivity and sensitivity, enabling researchers to visualize biological processes at the single-molecule level. By coupling vibrations to fluorescence, BonFIRE combines the strengths of both techniques, providing rich chemical information and the ability to image entire cells or single molecules. The researchers also demonstrate the ability to tag biomolecules with different colors, revealing the molecular diversity of life in stunning detail.